吸入性损伤气道内给药目标靶向治疗  

Goal-targeted therapy of inhalation injury with intratracheal delivery of drugs

作　　者：郭光华[1] 孙威[1] Guo Guanghua;Sun Wei(Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Chin)

机构地区：[1]南昌大学第一附属医院烧伤科,330006

出　　处：《中华烧伤杂志》2018年第7期445-449,共5页Chinese Journal of Burns

基　　金：国家临床重点专科建设项目（国卫办医函[2013]544号）;国家自然科学基金（81760342）;卫生行业科研专项（201202002）;教育部创新幽队项目（1210013003）;江西省自然科学基金重点项目（20171ACB20031）;江西省科学技术厅重点研发计划重点项目（20171ACG70004）;江西省教育厅科学技术研究重点项目（GTT160019）;汀西省科技厅赣鄱英才555工程领军人才培养计划（1210013001）

摘　　要：重度吸入性损伤早期气道管理和呼吸支持至关重要。气道内给药相比其他给药方式，具有呼吸道局部药物浓度高、起效快、疗效确切以及全身不良反应少等优势，越来越受到人们的重视。近年来，可用于气道吸入的药物种类日益增多，除了常用的支气管扩张剂、黏液溶解剂和糖皮质激素外，还包括抗炎剂、抗氧化剂、抗凝剂等。经气道内药物吸入作为一种目标靶向治疗方法，对改善吸入性损伤患者预后具有重要意义。Early airway management and respiratory support are essential for severe inhalation injury. Intratracheal delivery of drugs is better than other methods of administration, because of its higher local drug concentration, faster and more precise effect, and less systemic adverse reactions. It attracts more and more attention at present. In recent years, a growing number of drugs can be used in intratracheal delivery, in addition to common bronchodilators, mucolytics, and glucocorticoids, there are anti-inflammatory agents, antioxidants, and anticoagulants, etc. It is of great significance to improve the prognosis of patients with inhalation injuries with intratracheal delivery of drugs in goal-targeted therapy.

关 键 词：烧伤 吸入性 气道内给药 吸入疗法 辅助通气 靶向治疗 

分 类 号：R644[医药卫生—外科学]