无毒、可降解离子液体氢氧化胆碱催化合成吡喃并[3,2-c]色烯衍生物  

Synthesis of Pyrano[3,2-c]chromene Derivatives Catalyzed by Non-toxic and Biodegradable Ionic Liquid Choline Hydroxide

作　　者：王英磊[1,2] 杜朝军[1,2] 刘学国[1,2] 张群安[1,2] WANG Ying-lei;DU Chao-jun;LIU Xue-guo;ZHANG Qun-an(School of Biological and Chemical Engineering,2.Henan Key Laboratory of Industrial Microbial Resources and Fermentation Technology, Nanyang Institute of Technology, Nanyang 473004, China ） , Huaxue Shiji, 2018,40 （ 7 ） , 687 - 690;69)

机构地区：[1]南阳理工学院生物与化学工程学院,河南南阳473004 [2]南阳理工学院河南省工业微生物资源与发酵技术重点实验室,河南南阳473004

出　　处：《化学试剂》2018年第7期687-690,694,共5页Chemical Reagents

基　　金：河南省科技攻关项目(182102310601);河南省高等学校重点科研项目(17B150007)

摘　　要：氯化胆碱是动物体内维持生理活动所必需的一种水溶性维生素,以其作为原料或主要骨架结构,制备而得的胆碱类离子液体具有良好的生物相容性和环境友好性。在安全无毒、可生物降解的离子液体氢氧化胆碱的催化作用下,芳香醛、丙二腈和4-羟基香豆素于水相中三组分“一锅煮”反应,以86%~96%的产率合成了一系列吡喃并[3,2-c]色烯衍生物。该方法反应条件温和,适用范围广泛,催化剂易回收利用,具有潜在工业应用价值。Choline chloride is a kind of necessary and water-soluble vitamin for maintaining physiological activities in animals.The choline-based ionic liquids have good biocompatibility and environmental friendliness,which were prepared with choline chloride as a raw material or a main skeleton structure.A series of pyrano[3,2-c]chromene derivatives were synthesized via one-pot threecomponent reaction of aromatic aldehyde,malononitrile and 4-hydroxycoumarin in aqueous medium,with non-toxic and biodegradable ionic liquid choline hydroxide as the catalyst,in yield of 86% ～ 96%. The mild reaction condition,wide substrate flexibility and easily recyclable catalyst,made this protocol more potential value in industrial application.

关 键 词：氢氧化胆碱 吡喃并[3 2-c]色烯 一锅煮 循环使用 

分 类 号：TQ463.2[化学工程—制药化工]