基于SIMULINK仿真的生理药动学模型研究  

Study of physiologically based pharmacokinetic model based on SIMULINK simulation

作　　者：言方荣[1] 周璐 张倩媛 朱惠红 王菲[1] YAN Fang-rong;ZHOU Lu;ZHANG Qian-yuan;ZHU Hui-hong;WANG Fei(Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 211198, China)

机构地区：[1]中国药科大学生物统计与计算药学研究中心,南京211198

出　　处：《中国新药杂志》2018年第13期1531-1537,共7页Chinese Journal of New Drugs

基　　金：国家社会科学基金资助项目(16BTJ021)

摘　　要：目的:动态描述药物浓度在人体内各组织器官的经时变化,了解药物在人体内的分布情况,为药物作用机制的研究奠定基础。方法:以全氟辛酸和全氟辛烷磺酸为例,使用MATLAB SIMULINK软件,分别建立生理药动学仿真模型,模拟已知的口服给药情况下药物在人体内血液和组织器官的浓度变化,并将模拟结果与实际测得的药物浓度进行分析对照来验证模型的有效性。结果:SIMULINK仿真模型的模拟结果与实测值基本吻合。结论:SIMULINK仿真模型能够正确反映该药物在人体内的变化,对药物的临床研究具有现实意义。Objective： To dynamically describe the time course change of drug concentration in human tissues and understand the distribution of drugs in the human body,thus to lay a foundation for the study of mechanism of drug action. Methods： The MATLAB SIMULINK software was used to establish the physiologically based pharmacokinetic simulation model for perfluorooctanoic acid and perfluorooctane sulfonic acid through oral administration and to simulate the drug concentration change in human tissues. To assess the validity of the simulation model,visual validation and statistical analysis were used to compare the simulation results with the experimental values. Results： The simulation results of the SIMULINK simulation model were in good agreement with the experimental values. Conclusion： SIMULINK simulation model can correctly reflect the drug concentration change in human,and the results from the dynamic simulation are of practical significance for clinical drug research.

关 键 词：生理药动学模型 动态仿真 多房室模型 

分 类 号：R96[医药卫生—药理学]