pH响应性阿维菌素/介孔硅的一步合成与释药性能  

One-Step Synthesis and Drug Release of pH-responsive Avermectin/Mesoporous Silica

作　　者：沈之川 梁志铿 周红军[1] 周新华[1] 徐华[1] 陈铧耀[1] SHEN Zhi-chuan;LIANG Zhi-keng;ZHOU Hong-jun;ZHOU Xin-hua;XU Hua;CHEN Hua-yao(Guangzhou Municipal Key Laboratory of Efficient Use of Agricultural Chemicals, College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China)

机构地区：[1]仲恺农业工程学院化学化工学院广州市农业化学品高效利用重点实验室

出　　处：《精细化工》2018年第7期1126-1130,共5页Fine Chemicals

基　　金：国家自然科学基金(21576303,21606262);广东省自然科学基金(2016A030313375)~~

摘　　要：以三嵌段共聚物F127[（EO）_（106）（PO）_（70）（EO）_（106）]为模板剂,正硅酸甲酯（TMOS）为硅源,阿维菌素（AVM）为模型药物,通过一步法合成了载药介孔硅材料（AVM/HOMS）,采用铜、锌、锰3种金属离子改性,制备了具有pH响应性的缓释材料AVM/Zn-HOMS、AVM/Cu-HOMS和AVM/Mn-HOMS,借助FTIR、SEM、N2吸附-脱附法和TGA表征了缓释材料,并研究了其在不同pH下的释放行为。结果表明：AVM/Zn-HOMS、AVM/Cu-HOMS和AVM/Mn-HOMS材料表面分别呈现层状、疏松多孔状以及气泡状结构,比表面积分别为308.581、101.218和318.011 m2/g,氮气吸附-脱附等温线类型为具有H2型滞后环的LangmuirⅣ型。AVM/Zn-HOMS和AVM/Cu-HOMS呈现良好的pH响应性,AVM/Mn-HOMS则未表现出明显的pH响应性,3种材料的缓释行为均可用Higuchi动力学模型描述,释放过程受扩散机制控制。Avermectin/mesoporous silica（AVM/HOMS） was prepared via one-step method by using F127 [（EO）_（106）（PO）_（70）（EO）_（106））] as template agent, methyl silicate（TMOS） as silicon source, avermectin as model drug. Subsequently, copper, zinc and manganese ions were used to modify the resultant material. Finally, three kinds of pH-responsive sustained release materials（AVM/Zn-HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS） were obtained. The prepared materials were characterized by FTIR, N2 adsorption-desorption, SEM and TGA. And their release behavior under different pH values was studied. The results showed that the surface of AVM/Zn-HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS were stratiform, multihole and bubbly, respectively. The specific surface areas of AVM/Zn-HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS were 308.581, 101.218 and 318.011 m2/g. The N2 adsorption-desorption isotherms of the three samples were the Langmuir Ⅳ type with hysteresis loops type H2. AVM/Zn-HOMS and AVM/Cu-HOMS showed excellent sensitivities to pH, while AVM/Mn-HOMS exhibited no obvious pH responsiveness. The release process of these materials could be described by Higuchi kinetic model and was controlled by diffusion mechanism.

关 键 词：一步法 阿维菌素 p H响应性 缓释 功能材料 

分 类 号：TQ450.6[化学工程—农药化工]