马海治瘫胶囊治疗脑中风后遗症的作用机理研究  

Functional Mechanism Research of Using Mahai Zhitan Capsule in the Treatment of Sequelae of Apoplexy

作　　者：蒙麦侠[1] 陈志永 陈瑞明[1] 杨智峰[1] 张小丽[1] MENG Maixia;CHEN Zhiyong;CHEN Ruiming(Academy of Traditional Chinese Medicine and Materia Medica of Shanxi Prov- ince （ Xi＇ an Shaanxi 710003, China)

机构地区：[1]陕西省中医药研究院,陕西西安710003

出　　处：《四川中医》2018年第6期82-84,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：西安市科技计划资助项目[编号:HM1123(4)]

摘　　要：目的:论证马海治瘫胶囊治疗脑中风后遗症的作用机理。方法:以步长脑心通胶囊为阳性对照药,通过小鼠急性脑缺血实验、耐缺氧实验、凝血时间实验、耳廓微循环实验,观察马海治瘫胶囊大、中、小剂量组对急性脑缺血小鼠存活时间、脑含水量、耐缺氧时间、凝血时间、耳廓微循环改善的影响作用。结果:马海治瘫胶囊大剂量组显著增加小鼠缺氧存活时间,显著延长小鼠凝血时间,与空白对照组比较均有显著性差异;马海治瘫胶囊大、中、小剂量组均显著扩张小鼠微血管口径,加快血流速度,与空白对照组比较有显著性差异。结论:马海治瘫胶囊具有增加小鼠缺氧存活时间、延长凝血时间以及有效改善机体微循环的作用,说明该药主要是通过提高脑中风后遗症患者大脑受损缺氧后的生物耐受性以及改善机体微循环来发挥综合治疗作用。Objective ： To investigate the mechanism of Mahai Zhitan Capsule in the treatment of sequelae of apoplexy. Meth- ods： Taking Buchang Xintong Capsule as positive control drug, the mice were experimented with acute cerebral ischemia and hy- poxia tolerance test, clotting time test, auricular microcireulation test, and were treated with Mahai Zhitan Capsule. The effect of Mahai Zhitan Capsule on the survival time, brain water content, resistance time to hypoxia, coagulation time and the improvement of microcirculation in the mice with acute cerebral ischemia. Results ： Mahai Zhitan Capsule significantly increased the survival time of hypoxie mieecompared with the controlled group ; Mahai Zhitan Capsule could significantly expand mouse microvascular di- ameter, and accelerated their blood flow velocity compared with negative controlled group. Conclusion： Mahai Zhitan Capsule can significantly increase the survival time of hypoxic mice, and effectively improve their microcirculation, indicating that the drug can relieve and treat the stroke sequelae to a certain extent.

关 键 词：马海治瘫胶囊 急性脑缺血 耐缺氧 凝血 耳廓微循环 

分 类 号：R285.5[医药卫生—中药学]