人体心脏纤维骨架及瓣膜三维模型的构建及其3D打印模型的应用探讨  

Construction of three-dimensional models of cardiac fibrous skeleton and valves and application of the 3D printed models

作　　者：张小勤 李颖[1] 谭立文[1] 张绍祥[1] ZHANG Xiaoqin;LI Ying;TAN Liwen;ZHANG Shaoxiang(Institute of Digital Medicine,Faculty of Biomedical Engineering and Imaging Medicine,Army Medical University（Third Military Medical University）,Chongqing,400038,Chin)

机构地区：[1]陆军军医大学(第三军医大学)生物医学工程与影像医学系、数字医学研究所,重庆400038

出　　处：《第三军医大学学报》2018年第14期1251-1257,共7页Journal of Third Military Medical University

基　　金：国家自然科学基金重大项目(61190122);重庆市社会事业与民生保障科技创新专项(CSTC2015shmszx120002);重庆市社会事业与民生保障科技创新专项重点研发项目(CSTC2017shms-zdyfX0015)

摘　　要：目的探讨利用中国可视化人体(Chinese visible human,CVH)数据集建立3D打印心脏纤维骨架及瓣膜(cardiac fibrous skeleton and valves,CFSV)模型的效果及应用价值。方法先将CVH数据集第5例(CVH5)高分辨率断层图像导入Amira软件,对CFSV结构进行分割并重建其三维模型,经平滑、简化后进行3D打印,然后对3D打印模型进行打磨、着色等后处理,最后对其进行测量和分析。结果成功完成CFSV三维模型的构建和3D打印。对比数字化三维模型和3D打印实体模型的直径测量数据(mm):在短轴上,三尖瓣环(tricuspid valve ring,TVR)(26.56 vs 26.48),二尖瓣环(mitral valve ring,MVR)(27.67 vs 26.08);在长轴上,TVR(42.64 vs 41.02),MVR(37.93 vs 38.74);两种模型测量值的差异δ为(0.62±1.19)mm。肺动脉瓣的面积和周长均比主动脉瓣略大,TVR的周长和面积比MVR大,TVR和MVR所在平面的角度相差约20.4°。结论利用CVH数据集建立3D打印CFSV模型,可完整展现人体心脏纤维骨架原位解剖空间,在复杂、不规则形态的测量上更具优势。Objective To construct a three-dimensional （3D） model of cardiac fibrous skeleton and valves （CFSV） using the Chinese Visible Human （CVH） dataset and explore the utility of the 3D printed model in clinical practice and in medical anatomy teaching. Methods The CVH5 high-resolution tomographic images were imported into Amira software for segmentation and reconstruction of the CFSV. The reconstructed 3D model was smoothed and simplified, and was then imported into the 3D printer for printing. Anatomical measurements were conducted following post-processing of the 3D printed model by polishing and coloring. Results The 3D model of CFSV was successfully reconstructed and printed. Anatomical measurements using the digital 3D model and the 3D printed model showed that the minor axis of the tricuspid valve ring （TVR） was 26.56 mm vs 26.48 mm, and that of the mitral valve ring （MVR） was 27.67 mm vs 26.08 mm; the long axis of the TVR was 42.64 mm vs 41.02 mm and that of the MVR was 37.93 mm vs mm 38.74 mm. The mean difference between the measurements on the 2 models was 0.62±1.19 mm. The measured area and the circumference of the pulmonary valve were slightly larger than those of the aortic valve. The perimeter and area of the TVR were larger than the MVR, and the angle between the planes of the TVR and the MVR was about 20.40. Conclusion The 3D printed model of the CFSV well displays the anatomical structures, with the advantages in measurement of complex and irregular structures.

关 键 词：心脏纤维骨架 心脏瓣膜 3D打印 解剖教学 临床应用 

分 类 号：R319[医药卫生—基础医学] R322.11