双频高强度聚焦超声换能器应用研究进展  

Progress in application of dual frequency high intensity focused ultrasound transducer

作　　者：刘欢 李发琪[1] LIU Huan;LI Fa-qi(Department of Biomedical Engineering of Chongqing Medical University,State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology,Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine,Chongqing 400016,China)

机构地区：[1]重庆医科大学生物医学工程学院省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室重庆市微无创医学协同创新中心,重庆400016

出　　处：《声学技术》2018年第3期243-247,共5页Technical Acoustics

基　　金：国家自然科学基金资助项目(11574039;11274404);重庆市前沿与应用基础研究计划一般项目(cstc2015jcyjA50001;csct2017jcyjB0218)

摘　　要：高强度聚焦超声(High Intensity Focused Ultrasound,HIFU)消融实体肿瘤已在临床治疗中展示出良好的应用前景。HIFU消融肿瘤技术由于其使靶区肿瘤组织瞬时升温至60℃以上,产生不可逆性凝固性坏死,同时不影响靶区外正常组织而被广泛应用。目前治疗用超声主要使用单频率高强度聚焦超声,但其临床应用的主要限制是靶区组织消融时间较长,靶区外正常组织损伤风险较大。缩短靶区组织消融时间,对于提高HIFU治疗效率,更好地应用于临床较为关键。在总结HIFU换能器的特性和影响HIFU治疗因素的基础上,综述了应用不同类型的双频HIFU换能器强空化和缩短靶区组织消融时间等方面的研究进展。High Intensity Focused Ultrasound（HIFU） has been shown a promising prospect in clinical applications. HIFU ablation technique is widely used because it could heat the target tumor tissues instantaneously up to more than 60？C, resulting in irreversible coagulation necrosis, without affecting the normal tissue outside the target area. At present, the single-frequency high-intensity focused ultrasound is mainly used in ultrasound therapy, but the main limitation of its clinical application is that the target tissue ablation time is longer and the risk of the normal tissue damage outside the target area is greater. Shortening the target tissue ablation time is vital for improving the efficiency of HIFU treatment and better clinical application. Based on summarizing the characteristics of HIFU transducers and the influencing factors of HIFU therapy, this paper reviews the research progress in the application of different types of dual-frequency HIFU transducers to enhancing cavitation and shortening the ablation time of target tissue.

关 键 词：高强度聚焦超声 聚焦超声换能器 双频 消融 

分 类 号：TB552[理学—物理]