金属硫蛋白基因多态性与昆明地区汉族2型糖尿病的相关性研究  

Association between the polymorphism of MT gene and type 2 diabetes mellitus

作　　者：颜穗珺 郭伟昌 周晓伟 李佳丽 乐小婧 董雪娥 宋滇平[1] 李会芳[1] YAN Suijun;GUO Weichang;ZHOU Xiaowei(Department of Diabetes Mellitus,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,Chin)

机构地区：[1]昆明医科大学第一附属医院糖尿病科,650032 [2]昆明市延安医院内分泌科 [3]昆明医科大学体育部

出　　处：《中国糖尿病杂志》2018年第7期529-533,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81160104、30760087); 云南省卫生科技计划项目(2017NS049)

摘　　要：目的 探讨金属硫蛋白(MT)1A基因rs8052394多态性与昆明地区汉族T2DM的相关性。方法 采用Taqman实时荧光定量PCR技术对257例T2DM患者(T2DM组)和108名健康对照(NC)组MT1A基因型进行检测。结果 T2DM组MT1A基因rs8052394A/A基因型频率及A等位基因频率高于NC组(χ~2=20.519、29.213,P<0.01)。Logistic回归分析显示,MT1A rs8052394A/A基因型携带者相对于A/G和G/G基因型携带者患T2DM的危险性增加。结论 昆明地区汉族人群MT1A基因rs8052394多态性可能与T2DM的发生有关,A等位基因可能增加T2DM的发病风险。Objective To investigate the association between rs8052394 polymorphism of MT1 A gene and type 2 diabetic mellitus（T2 DM）in Kunming Han Chinese. Methods The genotype of MT1 A gene rs8052394 was detected by Taqman PCR in 257 Kunming han T2 DM patients and 108 normal controls（NC）. Results The rs8052394 A/A genotype and A allele frequency of MT1 Agene in T2 DM group were significantly higher than that in NC group（χ^2=20.519,29.213,P〈0.01）.Logistic regression analysis showed that the risk of T2 DM increased in MT1 Ars8052394 A/A genotype carriers compared with those with A/G and G/G genotypes. Conclusion The MT1 Ars8052394 gene polymorphism may be associated with the development of T2 DM in Kunming Han Chinese.The A allele may increase the risk of T2 DM.

关 键 词：金属硫蛋白1A基因 多态性 糖尿病 2型 Taqman实时荧光定量PCR 

分 类 号：R587.1[医药卫生—内分泌]