精子形态与体外受精-胚胎移植妊娠结局的研究  

Study on the Relationship between Sperm Morphology and the Pregnancy Outcome of In-vitro Fertilization Embryo Transfer

作　　者：王艳红[1] 田秀珠[2] 王治鸿[2] 刘翔华[1] 张晋丹 张红梅[2] 杨丽洪 高利萍[2] 常换英[2] WANG Yan-hong;TIAN Xiu-zhu;WANG Zhi-hong;LIU Xiang-hua;ZHANG Jin-dan;ZHANG Hong-mei;YANG Li-hong;GAO Li-ping;CHANG Huan-ying(The First Clinical Medical College of Shanxi Medical University,Taiyuan Shanxi 030001;First Hospital of Shanxi Medical University Reproductive Center,Taiyuan Shanxi 030001)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院生殖中心,山西太原030001

出　　处：《世界最新医学信息文摘》2018年第16期1-3,5,共4页World Latest Medicine Information Electronic Version

基　　金：自然科学基金;项目编号:201701D121174

摘　　要：目的探讨促排卵前男方精子形态参数对常规体外受精-胚胎移植(IVF-ET)妊娠结局的预测价值和影响。方法将502个常规IVF-ET治疗前男方的正常形态精子百分率进行分组,分别为A组:<4%,B组:≥4%~<15%,C组:≥15%,比较各组间的精子功能参数和其IVF-ET周期中的受精率、正常受精率、卵裂率、优胚率、种植率及妊娠率等指标是否有差异。结果 (1)各组间的精液量无差异(P>0.05),而精液密度及前向运动精子百分率差异有显著性(P<0.01);(2)各组间的受精率、卵裂率及优胚率等指标差异均无显著性(P>0.05),仅有<4%组的受精率略低于其它两组,而≥15%组的正常受精率略高于其它两组;(3)各组间的种植率、生化与临床妊娠率、异位妊娠率、早期与晚期流产率及活产率均无显著差异(P>0.05)。但早期流产率随正常形态精子百分率的增加而呈逐渐下降趋势。结论精子形态与其功能密切相关;仅通过精子形态检测来预测IVF-ET的妊娠结局有一定的局限性。Objective To study the predictive value and effects of the sperm morphological parameters on the pregnancy outcome of normal in-vitro fertilization embryo transfer（IVF-ET） before ovulation induction. Methods Divide the sperm percentages of 502 normal male sperms before normal in-vitro fertilization embryo transfer（IVF-ET） into 3 groups： Group A： 4%, Group B ≥4%~15% and Group C： ≥15%; and then compare the functional parameters of different groups of sperm and their fertilization rates, normal fertilization rates, cleavage rates, good-quality embryo rates, implantation rates and pregnancy rates during the IVF-ET process. Results（1） No differences in semen volumes between the three groups（P〉0.05）, but significant differences in sperm density and the percentage of sperms swimming forward（P〈0.01）;（2）No apparent differences in fertilization rates, cleavage rates and good-quality embryo rates, implantation rates（P〉0.05）, only the fertilization rates of Group A are slightly lower than those of other two groups, whereas the normal fertilization rates of Group C are slightly higher than those of other two groups;（3） No significant differences in implantation rates, biological and clinical pregnancy rates, early and late abortion rates, and live birth rates（P〉0.05）. Conclusion Though the morphology of sperm is closely related with its functions, prediction of pregnancy outcome of IVF-ET merely by sperm morphology is not entirely reliable.

关 键 词：精子形态与功能 体外受精-胚胎移植 妊娠结局 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]