北京市房山区育龄妇女与其新生儿麻疹抗体水平比较研究  

The study on levels of measles maternal antibody among puerperants and newborns in Fangshan district,Beijing

作　　者：吴涛[1] 辛丹[1] 高舒[1] 周伟[1] 阚震[1] 黄少平[1] WU Tao;XIN Dan;GAO Shu;ZHOU Wei;KAN Zhen;HUANG Shao-ping(Fangshan District Center for Disease Control and Prevention,Beijing 102488,China)

机构地区：[1]北京市房山区疾病预防控制中心,102488

出　　处：《首都公共卫生》2018年第3期129-131,共3页Capital Journal of Public Health

摘　　要：目的了解北京市房山区产妇及新生儿麻疹Ig G抗体水平及相互关系,为控制小月龄婴儿发病提供科学依据。方法抽取2016年5-12月在房山区6家医院产科生产的300对产妇和新生儿作为调查对象,对其进行问卷调查并采集产妇静脉血和新生儿脐带血,采用酶联免疫吸附法检测麻疹Ig G抗体。结果房山区产妇麻疹抗体阳性率为66.30%,抗体几何平均浓度(GMC)为312.58 m IU/m L,不同户籍、不同年龄产妇的麻疹抗体阳性率比较差异无统计学意义((P>0.05)。新生儿麻疹抗体阳性率为88.74%,GMC为543.87 m IU/m L,不同性别、不同体重新生儿的麻疹抗体阳性率和GMC比较差异无统计学意义(P>0.05)。新生儿麻疹抗体阳性率和GMC均高于母亲,差异有统计学意义(P<0.05)。新生儿麻疹抗体水平与母亲的抗体水平呈正相关,相关系数为0.865。新生儿麻疹抗体水平随着母亲的抗体水平增高而增高。结论产妇麻疹抗体水平的高低是影响婴儿胎传抗体水平的重要因素。育龄妇女加强免疫含麻疹成分疫苗,是现阶段控制小月龄婴儿麻疹发病的重要手段。Objective To understand the interrelationship of the measles Ig G antibody levels between pregnant women and newborns in Fangshan district of Beijing,and to provide scientific evidence for disease control in young children. Methods300 puerperants and their newborns came from six hospitals in Fangshan district were selected as investigation object from May to December,2016. Blood samples of mothers and babies were collected and tested by enzyme-linked immunosorbent assay（ ELISA） to detect measles Ig G antibody. Questionnaire survey also employed in the study. Results The positive rate of measles antibody in puerperants was 66. 30% in Fangshan district and the geometric mean concentration（ GMC） of antibody was 312. 58 m IU/ml. The measles antibody positive rates had no significant difference in different household registration and age groups（ P 0. 05）. The positive rate in newborns was 88. 74% and GMC was 543. 87 m IU/m L. The positive rate and GMC among newborns were no difference in different gender and birth weight groups（ P 0. 05）. However,the positive rate and GMC of babies were significantly higher than that of their mothers（ P〈0. 05）. Neonatal measles antibody levels were positively correlated with their mother levels,and the correlation coefficient was 0. 865. Neonatal antibody levels increased with the mother＇s level increasing. Conclusion The levels of maternal measles antibody was one of the important influence factors of babies antibody levels. Immunization for women of fertile age with measles vaccine played an important role in measles control in infants.

关 键 词：麻疹 母传抗体 产妇 新生儿 

分 类 号：R511.1[医药卫生—内科学]