聚乙二醇修饰脂质小分子在胶束给药系统中的研究进展  

Research progress of polyethylene glycol modified small lipids in micellar drug delivery system

作　　者：鲁晓雨 方敏 李宁[2] 卢山 陈西敬 LU Xiaoyu;FANG Min;LI Ning;LU Shan;CHEN Xijing(Clinical Pharmacokinetics Laboratory,School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China;National Experimental TeachingDemonstration Center of Pharmacy,China Pharmaceutical University,Nanjing 211198,China;College of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]中国药科大学基础医学与临床药学学院临床药物代谢动力学研究室,江苏南京211198 [2]中国药科大学药学国家实验教学示范中心,江苏南京211198 [3]湖北中医药大学药学院,湖北武汉430065

出　　处：《药学研究》2018年第7期416-419,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81473272)

摘　　要：脂质分子因具有无毒性,无免疫源性以及良好的生物兼容性,广泛应用于药物载体研究中。经聚乙二醇修饰的脂质具有双亲性,在水中可自组装形成胶束。该类聚合物载体能够增强药物的溶解度及稳定性,改善药物在体内的药动学行为,增强疗效等,在纳米给药系统中具有广阔的应用前景。本文综述了在胶束给药系统中应用较多的聚乙二醇化脂质小分子,主要包括聚乙二醇修饰的磷脂,胆固醇,脂肪酸等。Lipids had been widely applied to the research about drug delivery carriers on account of its no toxicity,noimmunogenicity and good biocompatibility.Polyethylene glycol （ PEG） modified lipids can self-assemble into micelles inwater due to its amphiphilicity.And these polymers have the characteristics of increasing aqueous solubility and stability ofhydrophobic compounds,improving the pharmacokinetic behavior and therapeutic effect.PEGylated lipids will be promisingcarriers in nano-drug delivery systems.In this paper,the applications of PEGylated small lipids in micellar delivery systemswere summarized,including PEGylated phospholipids,cholesterol and fatty acids.

关 键 词：胶束 脂质 聚乙二醇 药物载体 

分 类 号：R943[医药卫生—药剂学]