尿黄体生成素半定量试纸检测结合超声监测卵泡在预测排卵中的临床应用价值  

Clinical application value of urinary luteinizing hormone semi-quantitative test paper detection combined with follicles monitoring using ultrasound in prediction of ovulation

作　　者：张亦心 赵青 吕丽华 郭薇 郭旭芳 马婧 张诺 朱序亭 高羽 王琇 ZHANG Yi-Xin;ZHAO Qing;LYN Li-Hua(Hebei Province Research Institute for Family Planning Science and Technology, Key Laboratory of Family Planning and Health Birth, National Health and Family Planning Comission, Shifiazhuang, Hebei 050071, China)

机构地区：[1]河北省计划生育科学技术研究院(国家卫生计生委计划生育与优生重点实验室),河北石家庄050071

出　　处：《中国妇幼保健》2018年第14期3255-3258,共4页Maternal and Child Health Care of China

基　　金：河北省卫生和计划生育委员会资助(20170455)

摘　　要：目的探讨尿黄体生成素(LH)半定量试纸检测结合超声监测卵泡在预测排卵中的临床应用价值,为人工授精时机的把握提供参考依据。方法选择2016年1-12月在河北省计划生育科学技术研究院生殖医学中心接受供精人工授精(AID)助孕治疗的704例共1 616个周期不孕症夫妇为研究对象,阴道超声监测卵泡发育及子宫内膜情况,并结合尿LH半定量试纸检测,综合判断排卵时间并确定授精时机。结果尿LH检测值以45 mU/ml临床妊娠率最高,为34.50%,其次临床妊娠率依次为尿LH检测值65 mU/ml、<25 mU/ml及25 mU/ml组,分别为31.44%、27.55%和22.96%,尿LH检测值<25 mU/ml及25 mU/ml与45 mU/ml组比较差异有统计学意义(均P<0.05);尿LH检测值25 mU/ml与65 mU/ml组比较差异有统计学意义(P<0.05)。1 616周期中,发生未破裂黄素化卵泡(LUF)有29个周期,占1.79%,以尿LH检测值<25 mU/ml组为最高,为2.78%,随着LH检测值的增加,LUF发生率呈下降趋势,尿LH检测值<25 mU/ml组与65 mU/ml组比较差异有统计学意义(P<0.05),其余组间差异无统计学意义(均P>0.05)。结论尿LH半定量试纸检测结合超声监测卵泡情况可以准确预测排卵率,当出现内源性LH检测值<25 mU/ml时,适时注射h CG,可提高排卵率和临床妊娠率,预防和降低LUF发生,相比血LH测定尿LH半定量试纸检测更具优势。Objective To explore the clinical application value of urinary luteinizing hormone（ LH） semi-quantitative test paper detection combined with follicles monitoring using ultrasound in prediction of ovulation,provide a reference basis for mastering the opportunity of artificial insemination. Methods From January to December in 2016,704 infertile couples（ 1 616 cycles） receiving artificial insemination with donor sperm（ AID） in Center for Reproductive Medicine in Hebei Province Research Institute for Family Planning Science and Technology were selected,transvaginal ultrasonography was used to monitor follicular development and endometrium,transvaginal ultrasonography combined with urinary LH semi-quantitative test paper detection was used to predict ovulation time and confirm insemination time comprehensively. Results The clinical pregnancy rate was the highest（ 34. 50%） when urinary LH level was 45 mU/ml. The clinical pregnancy rates were 31. 44%,27. 55%,and 22. 96%,respectively when urinary LH levels were 65 mU/ml,〈25 mU/ml,and 25 mU/ml. There were statistically significant differences in the clinical pregnancy rate between urinary LH level〈25 mU/ml group and LH = 25 m IU/ml group,LH = 45 m IU/ml group（ P〈0. 05）. There was statistically significant difference in the clinical pregnancy rate between LH = 25 m IU/ml group and LH = 65 m IU/ml group（ P〈0. 05）. Among 1 616 cycles,29 cycles had luteinized unruptured follicles（ LUF）,accounting for1. 79%. The incidence rate of LUF in LH level〈25 mU/ml group was the highest,which was 2. 78%. The incidence rate of LUF showed a decreasing trend with the increase of LH levels. There was statistically significant difference in the incidence rate of LUF between LH 25 m IU/ml group and LH = 65 m IU/ml group（ P〈0. 05）,while there was no statistically significant difference among the other groups（ P〉0. 05）. Conclusion Urinary LH semi-quantitative test paper detection combined with follicles monitoring using ultrasound can accurately

关 键 词：尿黄体生成素半定量检测 超声 排卵 临床结局 分析 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]