酒石酸布托啡诺超前镇痛应用于开腹子宫切除术后患者镇痛效果观察  

The Effect of Postoperative Analgesia with Butorphanol as a Preemptive Analgesic in Patients Undergoing Abdominal Hysterectomy

作　　者：姚健春[1] 王玉婷[1] 许德奖[1] 肖清玉 YAO Jian-chun;WANG Yu-ting;XU De-jiang;XIAO Qing-yu(Department of Anesthesiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China)

机构地区：[1]汕头大学医学院第一附属医院麻醉科,广东汕头515041

出　　处：《汕头大学医学院学报》2018年第2期99-100,共2页Journal of Shantou University Medical College

摘　　要：目的:观察酒石酸布托啡诺超前镇痛在开腹子宫切除术后镇痛的应用效果。方法:选取2016-04—2017-04于我院行腰硬联合麻醉下开腹子宫切除手术患者共80例,ASAⅠ~Ⅱ级,随机分为2组(n=40):实验组和对照组,分别于麻醉开始前30 min静脉缓慢注射酒石酸布托啡诺注射液2 mg或生理盐水2 m L,观察出室即刻、术后2、4、8、12 h患者视觉疼痛评分(Visual Analogue Scale,VAS)及患者术后12 h内镇痛泵按压次数,并记录恶心呕吐等不良反应的发生情况。结果:两组患者出室即刻、术后2、4、8、12 h VAS评分差异无统计学意义,对照组患者12 h内患者自控硬膜外镇痛(Patient-controlled Epidural Analgesia,PCEA)次数高于实验组(P<0.05)。两组患者术后均未观察到恶心呕吐、呼吸抑制等不良反应。结论:酒石酸布托啡诺作为新型的阿片类受体激动拮抗剂具有良好的镇痛效果,可以将其作为超前镇痛药物用于妇科开腹子宫切除手术的术中及术后镇痛。Objective： To observe the effect of postoperative analgesia with Butorphanol as a preemptive analgesic in patients undergoing abdominal hysterectomy. Method： Eighty patients, with ASA grade of I or II, who required abdominal hysterectomy under combined spinal-epidural anesthesia from April 2016 to April 2017 wererecruited and randomly divided into two groups（n=40）： Butorphanol preemptive analgesia group（Group B） and control group（Group C）. Patients in Group B were injected intravenously with 2 mg of Butorphanol 30 minutes before anesthesia, while patients in Group C with 2 mL of normal saline. The visual analogue scale（VAS） scoreswere recorded when patients left the operation rooms and 2, 4, 8 and 12 hours postoperatively. Numbers ofPatient-controlled Epidural Analgesia（PCEA） in 12 hours postoperatively and any adverse events includingnausea and vomiting were also recorded. Results： There was no significant difference in VAS scores between Group B and Group C when patients left the operation rooms and 2, 4, 8 and 12 hours postoperatively.（P〈0.05）. Numbers of PCEA in 12 hours postoperatively were larger in Group C than in Group B（P〈0.05）. Adverseeffects such as nausea, vomiting and respiratory depression were not noted. Conclusion： Butorphanol, a newopioid receptor agonist and antagonist, could be used as a preemptive analgesic for intraoperative andpostoperative analgesia in patients undergoing abdominal hysterectomy.

关 键 词：布托啡诺 超前镇痛 开腹子宫切除术 

分 类 号：R971.2[医药卫生—药品]