缺氧诱导因子-1α在免疫反应中的作用  

The function of hypoxia inducible factor-1α in immune response

作　　者：林鹏 万聪 孙博[1] Lin Peng;Wan Cong;Sun Bo(Department of Neurobiology,Harbin Medical University,Harbin 150081,China;The Key Laborato-ry of Myocardial Ischemia,Ministry of Education,Department of Cardiology,2nd Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学神经生物教研室,150081 [2]哈尔滨医科大学附属第二医院省部共建心肌缺血实验室,150081

出　　处：《国际免疫学杂志》2018年第3期354-359,共6页International Journal of Immunology

摘　　要：炎症和缺氧是相互依存的，缺氧诱导因子-1α（hypoxia inducible factor-1α，HIF-1α）作为缺氧的关键调节剂，会根据氧含量的差异作用于不同的通路进而发挥作用，然而由于病原体感染和自身免疫性疾病的种类是复杂多样的，HIF-1α在不同的疾病中扮演的角色也将各不相同，因此有必要对HIF-1α在各种免疫细胞、病原体感染和自身免疫性疾病的炎症和病理活动中的作用进行综述。There is an interdependence between inflammation and anoxia. Hypoxia inducible factor-1α （HIF1α）, as a crucial adjuster of anoxia, acts differently through multiple pathways according to differen oxy- gen content. The role of HIF-1α is also different in different diseases,because of the diversity of pathogens infec- tion and autoimmune diseases. Therefore, it is necessary to review the role of HIF-1αi n inflammatory and patho- logical activities in various immune cells,pathogen infections and autoimmune diseases.

关 键 词：缺氯诱导因子-1α 自身免疫性疾病 病原体感染 

分 类 号：R392[医药卫生—免疫学]