颈动脉体在慢性间歇低氧诱导高血压中的调控作用  

Regulation of carotid body in chronic intermittent hypoxia-induced hypertension

作　　者：周秀芳[1] 胡克[1] Zhou Xiufang;Hu Ke(Department of Respiratory Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,Chin)

机构地区：[1]武汉大学人民医院呼吸科,430060

出　　处：《国际呼吸杂志》2018年第13期1016-1020,共5页International Journal of Respiration

基　　金：国家自然科学基金（81370181）

摘　　要：阻塞性睡眠呼吸暂停（OSA）是发生高血压的独立危险因素，而慢性间歇低氧（CIH）是OSA引发高血压的主要病理生理学基础。近年来的研究显示，OSA患者及CIH动物模型均表现出交感神经过度激活同时有呼吸循环反应增强，提示CIH可增强外周化学感受器的活性；进一步研究也证实CIH可增强颈动脉体化学感受性活性，从而使交感神经过度激活，导致高血压，提示颈动脉体在CIH诱导高血压中起重要作用。本文主要综述颈动脉体在CIH诱导高血压中的调控作用。Obstructive sleep apnea （OSA） chronic intermittent hypoxia （CIH） is recognized is an independent risk factor for hypertension, and as the most important pathophysiologie factor for developing hypertension of OSA patients. Recent researches demonstrate that OSA patients as well as CIH animal models display sympathetic hyperactivity and potentiated cardiorespirartory alterations, which suggest CIH may enhance the peripheral chemoreflex. Futher studies also support the hypothesis that CIH increases sympathetic outflow and leads to hypertension through enhancing carotid body chemosensory potentiation,indicating that carotid body plays an important role in CIH-induced hypertension. In this review, we will summarize the contribution of carotid body to CIH induced hypertension.

关 键 词：阻塞性睡眠呼吸暂停 慢性间歇低氧 高血压 颈动脉体 氧化应激 

分 类 号：R544.1[医药卫生—心血管疾病] R766[医药卫生—内科学]