α_1-受体阻滞剂在输尿管下段结石输尿管镜钬激光碎石术后患者中的应用效果  

Application effect of α_1-receptor blocker in patients with distal ureteral calculus after ureteroscopic holmium laser lithotripsy

作　　者：聂文辉 NIE Wen-hui(Department of Urology,General Hospital of Sichuan Petroleum Administration Bureau,Chengdu 610213,China)

机构地区：[1]四川石油管理局总医院泌尿外科,四川省成都市610213

出　　处：《临床合理用药杂志》2018年第18期83-84,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨α1-受体阻滞剂在输尿管下段结石输尿管镜钬激光碎石术后患者中的应用效果。方法选取四川石油管理局总医院2015年4月—2017年6月收治的输尿管下段结石患者100例,随机分为研究组和对照组,各50例。患者均经输尿管镜钬激光碎石术治疗,研究组患者术后给予α1-受体阻滞剂坦索罗辛治疗。比较两组手术时间、结石大小及结石病程、残余结石率、术后哌替啶用量及肾绞痛发生情况。结果两组患者手术时间、结石大小及结石病程比较,差异无统计学意义(P>0.05)。研究组患者残余结石率低于对照组(P<0.05)。研究组患者哌替啶用量少于对照组,肾绞痛发生率低于对照组(P<0.05)。结论α1-受体阻滞剂在输尿管下段结石输尿管镜钬激光碎石术后患者中的应用效果明显,可提高排石成功率,减少术后镇痛剂使用量及肾绞痛。Objective To investigate the application effect of α1-receptor blocker in patients with distal ureteral calculus after ureteroscopic holmium laser lithotripsy.Methods A total of 100 cases of patients with distal ureteral calculus were selected from April 2015 to June 2017 in General Hospital of Sichuan Petroleum Administration Bureau, which were randomly divided into study group and control group, 50 cases in each.All patients were treated with ureteroscopic holmium laser lithotripsy, study group was given α1-receptor blocker.The operation time, the size of stone and the course of calculi, rate of residual stones, the dosages of dolantin and the incidence of renal colic were compared between the two groups.Results There was no significant difference of operation time, the size of stone or the course of calculi was found between the two groups（ P〉0.05 ）. The rate of residual stones in study group was lower than control group （ P〈0.05 ） .The study group of the dosages of dolantin were less than control group, and the incidence rate of renal colic was lower than control group （ P〈0.05 ） .Conclusion The α1-receptor blocker has an obviously application effect in patients with distal ureteral calculus after ureteroscopic holmium laser lithotripsy, which can improve the success rate of stone removal, reduce the dosages of postoperative analgesic and the occurrence of renal colic.

关 键 词：输尿镜结石 Α1-受体阻滞剂 坦索罗辛 治疗结果 

分 类 号：R699.4[医药卫生—泌尿科学]