多孔二氧化硅微球在药物控释载体中的应用(连载三)  

Application of Porous Silica Spheres Carriers for Controlled Drug Delivery System

作　　者：任小宁 罗志强[1,2] 李昱 万影[1,2] 杨祥良[1,2] REN Xiaoning;LUO Zhiqiang;LI Yu;WAN Ying;YANG Xiangliang(National Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan 430074,China;College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China;State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,School of Materials Science ＆ Engineering,Wuhan University of Technology,Wuhan 430070,China)

机构地区：[1]华中科技大学国家纳米药物工程技术研究中心,武汉430074 [2]华中科技大学生命科学与技术学院,武汉430074 [3]武汉理工大学材料科学与工程学院材料复合新技术国家重点实验室,武汉430070

出　　处：《医药导报》2018年第8期925-930,共6页Herald of Medicine

基　　金：国家重点研究计划项目(2017YFC1103800)

摘　　要：多孔二氧化硅微球作为药物载体具有较大的内外比表面积及孔体积,可调控孔尺寸,良好的胶体稳定性和生物相容性,容易功能化修饰等特性,在纳米药物制剂领域受到的广泛关注。该文首先对实心等级多孔、核壳结构、中空球结构的二氧化硅微球的制备策略进行综述;其次探讨多孔二氧化硅微球用于可控药物释放体系的各种响应手段;最后对多孔二氧化硅微球在药物控释方面的应用进行概述。With high internal and external surface area and pore volume,adjustable pore size,colloidal stability,favorable biocompatibility,diverse surface chemistry,scientists in nanomedicine field pay intensive attention on porous silica spheres.In this review,at first,the fabrication strategy of porous silica spheres with different structure,such as hierarchical solid sphere,core shell spheres and porous hollow spheres was discussed; then explore the various responsive strategy used for controllable drug delivery system; and lastly review the application of porous silica carriers in controlled drug delivery.

关 键 词：多孔二氧化硅微球 药物控释载体 纳米制剂 

分 类 号：R945[医药卫生—微生物与生化药学]