疏水化改性羟乙基纤维素两亲性聚合物的合成及自组装行为  

Synthesis and self-assembly behavior of hydrophobic modified hydroxyethyl cellulose amphiphilic polymers

作　　者：杨晓旭 张丽 刘真真 王兴 郭延柱 YANG Xiaoxu;ZHANG Li;LIU Zhenzhen;WANG Xing;GUO Yanzhu(School of Light Industry and Chemical Engineering,Dalian Polytechnic University,Dalian 116034,China;State Key Laboratory of Pulp and Paper Engineering,South China University of Technology,Guangzhou 510640,China)

机构地区：[1]大连工业大学轻工与化学工程学院,辽宁大连116034 [2]华南理工大学制浆造纸工程国家重点实验室,广东广州510640

出　　处：《大连工业大学学报》2018年第4期257-262,共6页Journal of Dalian Polytechnic University

基　　金：国家自然基金青年基金项目(31500493);辽宁省自然科学基金重点项目(20170520300);制浆造纸工程国家重点实验室开放基金项目(201747);大连市青年科技之星项目(2017RQ036)

摘　　要：以羟乙基纤维素(HEC)为起始物,通过羟基与卤代烷烃之间的醚化改性制备了长碳链疏水化改性羟乙基纤维素聚合物(HMHEC)。通过改变卤代烷烃的种类(溴代十二烷和溴代十八烷)和用量,实现了HMHEC中疏水链段长度和含量的调控。利用FT-IR、1 H-NMR、TGA、TEM、DLS和荧光光谱等技术对HMHEC聚合物的结构、物理性能以及自组装行为进行了表征。结果表明,聚合物在水溶液中可自组装形成均一的球形纳米胶束,平均粒径范围为83~250nm,临界胶束质量浓度为282μg/mL。以疏水性抗癌药物紫杉醇(PTX)和吴茱萸碱(EVO)作为模型药物,利用超声透析法实现了胶束对药物的包载。提高聚合物中疏水链段的长度,有利于药物的包封率增加,聚合物胶束对PTX和EVO的最大包封率分别为79.5%和96.3%。A series of long-carbon chain hydrophobic modified hydroxyethyl cellulose polymers（HMHEC）were prepared by etherification reaction between hydroxyl group and alkyl halides using hydroxyethyl cellulose（HEC）as the starting material.The lengths and contents of hydrophobic alkyl chain in polymers were adjusted by changing the amounts and types of alkyl halides.The chemical structures,physical properties and self-assembly behavior of polymers were characterized by FT-IR,1 H-NMR,TGA,TEM,DLS and fluorescence spectroscopy techniques.The results indicated that HMHEC polymers were able to self-assemble into spherical nano-micelles with particle size ranging from 83 to 250 nm and critical micelle concentration of 282μg/mL.The hydrophobic paclitaxel（PTX）and evodiamine（EVO）were used as model drugs in order to investigate the drug loading ability of HMHEC micelles.With the increasing of the hydrophobic length,the encapsulation efficiency of PTX or EVO in micelles was increased.The highest encapsulation efficiencies of PTX and EVO in nanomicelles were 79.5% and 96.3%,respectively.

关 键 词：两亲性纤维素 疏水改性 自组装 纳米胶束 药物载体 

分 类 号：TS743.9[轻工技术与工程—制浆造纸工程] TQ314.1[化学工程—高聚物工业]