合肥地区新婚妇女叶酸参考值的制定及其与饮食模式的相关性研究  

Study on the folic acid reference standard and its correlation with dietary patterns in newly-married women in Hefei

作　　者：谢钱茹[1,2] 蔡横 郭锋 郝加虎 Xie Qianru;Cai Heng;Guo Feng(Dept of Maternal and Child Health Care,School of Public Health,Anhui Medical University,Hefei 230032;Dept of Maternal Health Care,Hefei Maternal and Child Health Care and Family Planning Service Centre,Hefei 230001)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,合肥230032 [2]合肥市妇幼保健计划生育服务中心妇女保健科,合肥230001

出　　处：《安徽医科大学学报》2018年第6期933-937,950,共6页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81072310);合肥市2013年科技计划项目(编号:2013-20)

摘　　要：目的制定合肥地区新婚妇女孕前叶酸参考标准,并探究合肥地区新婚妇女孕期叶酸水平与饮食模式之间的关系。方法根据合肥地区的地理分布,选取2 500名20~35岁新婚女性进行问卷调查,留取研究对象血液标本进行血清叶酸检测,同时测量研究对象身高、体重。结果研究对象血清叶酸水平呈正偏态分布。将研究对象叶酸水平低于P5(11.63 nmol/L)界定为低叶酸水平。月收入水平、体质量指数(BMI)越高的新婚女性其血清叶酸水平越低,不同地区新婚女性血清叶酸水平存在差异,差异均有统计学意义(P<0.05)。15个条目的《新婚妇女孕前饮食模式问卷》(传统型、动物蛋白型、营养型、饮料型4个维度)具有良好的信效度。低水平营养型饮食是新婚妇女血清叶酸水平偏低的危险因素,低水平和高水平饮料型饮食是叶酸水平偏低的保护因素,差异均有统计学意义(P<0.05)。结论合肥地区新婚女性血清叶酸水平低于11.63 nmol/L界定为低叶酸水平。新婚妇女孕前饮食模式对血清叶酸水平具有一定影响。Objective To establish folic acid reference standards,and to explore the relationship between folic acid and dietary patterns among newly-married women in Hefei. Methods This study selected 2 500 newly married women aging from 20 to 35 years. Blood samples of the participant were collected for serum folic acid testing. In addition,participants have been investigation by questionnaire,and have physical examination. Results In this study,the results indicated that the values of serum folic acid revealed positive skew distribution. The level of serum folic acid lower than the P5（ 11. 63 nmol/L） had been defined as low folic acid level in our study. Newly-married women with higher monthly income and BMI had lower level of serum folic acid,and the different level of serum folic acid were varies from different areas（ P 〈 0. 05）. ＂Newly-married Women ’s Dietary Pattern Questionnaire＂with 15 items（ including traditional pattern,animal protein pattern,nutrition pattern,and beverage pattern 4 dimensions） had good reliability and validity. The low-level of nutrition pattern was the risk factor,while the lowlevel and high-level beverage pattern were protective factors of lower serum folic acid amongnewly-married women（ P 〈 0. 05）. Conclusion The low-level of serum folic acid has been defined that the level of serum folic acid amongnewly-married women is lower than 11. 63 nmol/L in Hefei area. The dietary patterns of newly-married women have a relationship with the serum folic acid level.

关 键 词：叶酸 参考标准 饮食模式 新婚 

分 类 号：R173[医药卫生—妇幼卫生保健]