三氧化二砷治疗胃癌的作用机制  

Research Progress on the Mechanism of Arsenic Trioxide in Treating Gastric Cancer

作　　者：邓运宗[1] 黄兴[1] 王红玲[1] 康斐[1] 王媛媛[1] 董旭辉[1] 贾润霞[1] 郭寒冰[1] DENG Yunzong;HUANG Xing;WANG Hongling;KANG Fei;WANG Yuanyuan;DONG Xuhui;JIA Runxia;GUO Hanbing(The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 45000)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008

出　　处：《中医学报》2018年第6期961-966,共6页Acta Chinese Medicine

基　　金：河南省科技厅2015科技攻关项目(152102310104)

摘　　要：三氧化二砷作为传统中药砒霜的主要成分,具有明显的抗胃癌肿瘤细胞的作用,近年来其作用机制研究主要体现在以下几个方面:(1)逆转耐药;(2)抑制胃癌MGC803细胞增殖;(3)通过P38微管聚合调节细胞凋亡;(4)调节PI3K/Akt信号通路,抑制胃癌细胞的增殖;(5)调节Akt信号通路,抑制HGC-27细胞的增殖;(6)调节血管内皮生长因子的表达;(7)调节胃癌细胞SGC-7901增殖;(8)调节胃癌NCI-N87细胞增殖;(9)调节胃癌组织Flt-1、KDR和VEGFR-3表达。虽然三氧化二砷治疗胃癌的研究取得了不小的进展,但仍处于初步探索阶段,其对肿瘤VEGF及其受体家族信号传导通路的影响所引发的生物学特性及其分子作用机制仍需进一步的研究。Arsenic trioxide as the main component of traditional Chinese medicine（ TCM） of arsenic,has obvious anti-tumor cells effect,in recent years,the mechanism of its action mainly reflects the following aspects：（1）reversal of drug resistance;（2）inhibiting MGC803 cells of gastric cancer;（3） regulating apoptosis by P38 micro-tube polymerization;（4） regulating the PI3K/Akt signaling pathway to inhibit the proliferation of gastric cancer cells;（5） regulating the Akt signaling pathway to inhibit the proliferation of HGC-27 cells;（6） regulating the expression of vascular endothelial growth factor;（7） regulating SGC-7901 proliferation of gastric cancer cells;（8）regulating the proliferation of gastric cancer NCI-N87 cells;（9）regulating the expression of KDR and VEGFR-3 in gastric carcinoma. Although As_2O_3 has made great progress in the treatment of gastric cancer,it is still in the preliminary stage of exploration,and the biological characteristics and molecular mechanism induced by its effect on tumor VEGF and its family signal transduction pathway need to be further studied.

关 键 词：胃癌 肿瘤 三氧化二砷 砒霜 作用机制 

分 类 号：R273.52[医药卫生—中西医结合]