足浴2号方治疗糖尿病周围神经病变临床研究  

Clinical Study on Foot Bath No.2 Prescription in Treating Diabetic Peripheral Neuropathy

作　　者：黄俊臣 马茂芝 赵明刚[1] 武永华[1] 王正环[1] 李岚 HUANG Junchen;MA Maozhi;ZHAO Minggang;WU Yonghua;WANG Zhenghuan;LI Lan(Puyang Hospital of Traditional Chinese Medicine,Puyang Henan China 45700)

机构地区：[1]濮阳市中医院,河南濮阳457000

出　　处：《中医学报》2018年第6期996-1000,共5页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2016ZY3042)

摘　　要：目的:观察足浴2号方治疗糖尿病周围神经病变的临床疗效及其对患者中医证候积分、感觉阈值评分、生存质量评分、炎症因子及血管内皮功能的影响。方法:138例糖尿病周围神经病变患者随机分为对照组(69例)与观察组(69例)。对照组给予西医常规治疗,包括降低血糖、控制血压、调节血脂代谢紊乱、营养神经等;观察组在对照组治疗基础上加用足浴2号方。比较两组患者治疗前后中医证候积分、足部压力感觉阈值评分及足部震动感觉阈值评分;检测两组患者治疗前后血清炎性因子水平:肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),白细胞介素-6(interleukin-6,IL-6);比较两组患者血管内皮功能指标:NO、可溶性细胞间黏附分子-1(soluble intercellular adhesion molecules-1,sICAM-1)、内皮素(endothelin-1,ET-1);比较两组患者生存质量各维度评分。结果:(1)治疗前,两组患者中医证候积分(U=0.523 1,P=0.601 8)、足部压力感觉阈值评分(U=0.682 2,P=0.496 2)、足部震动感觉阈值评分(U=0.987 9,P=0.324 9)比较,差异无统计学意义。治疗后,观察组中医证候积分显著低于对照组(U=7.350 7,P=0.000 0),足部压力感觉阈值评分显著高于对照组(U=2.817 1,P=0.005 6),足部震动感觉阈值评分显著高于对照组,差异有统计学意义(U=2.767 5,P=0.006 4)。(2)观察组治疗效果显著优于对照组,差异有统计学意义(t=2.666 2,P=0.003 8)。(3)治疗前,两组患者IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者IL-6、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。(4)治疗前,两组患者NO、sICAM-1、ET-1水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者NO高于对照组,sICAM-1、ET-1低于对照组,差异有统计学意义(P<0.05)。(5)治疗后,观察组患者各维度评分均高于对照组,差异有统计学意义(P<0.05)。(6)所有患者治疗过程中均未出现血常规、肝肾功能异常及Objective： To observe the clinical effect of foot bath No. 2 prescription on diabetic peripheral neuropathy and its effect on TCM syndrome score,sensory threshold score,quality of life score,inflammatory factors and vascular endothelial function. Methods： 138 cases of diabetic peripheral neuropathy patients were randomly divided into the control group（ 69 cases） and the observation group（ 69 cases）. The control group was given western medicine routine treatment,including lowering blood sugar,controlling blood pressure,regulating dyslipidemia,nutrition nerve and so on,and the observation group was treated with foot bath No. 2 prescription on the basis of control group. The scores of TCM syndromes,foot pressure sensation threshold and foot vibration sensation before and after treatment were compared between the two groups,and the levels of serum inflammatory factors： tumor necrosis factor-α（ TNF-α） and interleukin-6（ IL-6） were measured before and after treatment in both groups. Comparison on the vascular endothelial function indexes of the two groups,such as： NO,soluble intercellular adhesion molecules-1（ sICAM-1）,endothelin-1（ ET-1）. The quality of life（ QOL） scores were compared between the two groups. Results：（1） Before treatment,comparison on TCM syndromes scores（ U = 0. 523 1,P = 0. 601 8）,foot pressure sensation thresholds score（ U = 0. 682 2,P = 0. 496 2）,foot vibration sensation thresholds score of the two groups（ U = 0. 987 9,P = 0. 324 9）,showed that there was not significantly different. After treatment,the score of TCM syndromes in the observation group was significantly lower than that in the control group（ U = 7. 350 7,P = 0. 000 0）,the foot pressure sensation threshold score was significantly higher than that in the control group（ U = 2. 817 1,P =0. 005 6）,and the foot vibration sensation threshold score was significantly higher than that in the control group（ U = 2. 767 5,P =0. 006 4）,and the difference was statistically significan

关 键 词：足浴2号方 糖尿病周围神经病变 中医证候积分 感觉阈值 炎症因子 血管内皮功能 中西医结合 

分 类 号：R259.872[医药卫生—中西医结合]