不稳定性心绞痛高尿酸血症及其痰湿瘀阻型与ACE基因插入/缺失多态性关系研究  

The Correlation Study on Patients with Unstable Angina Hyperuricemia of Phlegm Dampness and Stasis Type and Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism

作　　者：张秀梅[1] 邵静[1] 邵清蔚 ZHANG Xiumei;SHAO Jing;SHAO Qingwei(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 450000;Henan University of Chinese Medicine,Zhengzhou Henan China 450046)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000 [2]河南中医药大学,河南郑州450046

出　　处：《中医学报》2018年第6期1080-1084,共5页Acta Chinese Medicine

基　　金：河南省科技攻关计划项目(122102310079)

摘　　要：目的:研究不稳定性心绞痛高尿酸血症及其痰湿瘀阻型与血管紧张素转换酶(angiotensin converting enzyme,ACE)基因插入/缺失多态性的关系。方法:选取2017年3月至2018年2月因不稳定性心绞痛住院的90例患者作为研究对象,依据血尿酸水平分为高尿酸组60例(痰湿瘀阻型30例,非痰湿瘀阻型30例)和尿酸正常组30例。所有患者均于入院第2天清晨空腹取血,进行ACE基因插入/缺失多态性检测。结果:不稳定性心绞痛合并高尿酸血症患者ACE基因插入/缺失多态性分布以DD型多见,且D等位基因频率高于尿酸正常组,两组比较,差异有统计学意义(P<0.01);高尿酸组中痰湿瘀阻型患者DD、ID型及D等位基因分布高于非痰湿瘀阻型者,两组比较,差异有统计学意义(P<0.05)。结论:ACE基因DD型和D等位基因与不稳定性心绞痛高尿酸血症及中医痰湿瘀阻型密切相关,而与I等位基因无关,提示高尿酸血症痰湿瘀阻型不稳定性心绞痛可能具有遗传特异性。Objective： To discuss the correlation on patients with unstable angina hyperuricemia of phlegm dampness and stasis type and angiotensin converting enzyme（ ACE） gene insertion/deletion polymorphism. Methods： From March 2017 to February 2018,90 patients in hospital with unstable angina were selected as study subjects. According to the level of serum uric acid,60 patients were divided into 30 cases of phlegm dampness and stasis obstruction,and 30 cases of non-phlegm-dampness-stasis type,and other30 cases of normal uric acid group. The angiotensin gene insertion/deletion polymorphism was detected on an empty stomach in all patients on the second day of admission. Results： The distribution of angiotensin gene insertion/deletion polymorphism in patients with unstable angina complicated with hyperuricaemia was mainly DD type,and the frequency of D allele was higher than that in the normal uric acid group,and the difference was statistically significant（ P 〈 0. 01）. The DD,ID and D allele distribution of the patients with phlegm-dampness and stasis resistance type were higher than those of non-phlegm-dampness-stasis type,and the difference was statistically significant（ P 〈 0. 05）. Conclusion： ACE DD gene type and D allele have relation with unstable angina hyperuricemia and phlegm dampness and stasis type,but have nothing to do with I allele,which suggests that hyperuricemia and phlegm dampness and stasis type unstable angina may have genetic specificity.

关 键 词：血管紧张素转换酶基因插入/缺失多态性 不稳定性心绞痛 高尿酸血症 痰湿瘀阻型 DD基因型 D等位基因 

分 类 号：R259.414[医药卫生—中西医结合]