慢性阻塞性肺疾病并心力衰竭患者血清胆碱酯酶活性变化及其临床意义  

change in serum cholinesterase activity in patients with chronic obstructive pulmonary disease and it's clinical value

作　　者：孙丽敏[1] 董绍臣[2] 刘宏丽[3] 乔华[2] 齐曦明[4] SUN Li-min;DONG Shao chen;LIU Hong li(The first hospital of Qinhuangdao,Qinhuangdao 066000,Chin)

机构地区：[1]秦皇岛市第一医院心血管内科,河北秦皇岛066000 [2]秦皇岛市第一医院呼吸内科,河北秦皇岛066000 [3]秦皇岛市第一医院神经内科,河北秦皇岛066000 [4]秦皇岛市第一医院中心实验室,河北秦皇岛066000

出　　处：《中国实验诊断学》2018年第7期1140-1142,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)伴心力衰竭患者血清胆碱酯酶活性变化其临床意义。方法选取2011年至2014年期间我院收治的慢性阻塞性肺疾病患者390例为研究对象,根据有无心力衰竭,分为单纯慢阻肺和慢阻肺合并心力衰竭两组患者,对两组患者血清胆碱酯酶活性进行比较分析。结果慢阻肺合并心力衰竭患者血清胆碱酯酶活性较单纯慢阻肺患者明显降低(P<0.01),且胆碱酯酶活性与NT-proBNP呈明显负相关(P<0.01)。结论慢阻肺患者血清胆碱酯酶活性降低提示并发心力衰竭,对判断慢阻肺患者预后具有一定价值。Objective To investigate the alteration of serum cholinesterase levels in patients with chronic obstructive pulmonary disease and it＇s clinical value.Methods 390 patients with chronic obstructive pulmonary disease in our hospital from 2011 to 2014 were chosen as the research object.All the COPD patients were divided into two groups according to with or without heart failure.Activity of serum cholinesterase in these two groups was were analyzed statistically.Results Activity of serum cholinesterase in COPD patients with heart failure was significantly decreased compared with COPD patients without heart failure（P〈0.01）.Activity of serum cholinesterase was negatively related with NTproBNP（P〈0.01）.Conclusion Significant decrease of activity of serum cholinesterase suggests possibility of complicating heart failure which is a valuable predictor for prognosis in patients with COPD.

关 键 词：血清胆碱酯酶 慢性阻塞性肺疾病 心力衰竭 

分 类 号：R563[医药卫生—呼吸系统] R541.61[医药卫生—内科学]