人细小病毒B19抗体及抗心磷脂抗体(aCL)在流产人群中的检测价值  

Detection Value of Human Parvovirus B19 Antibody and Anticardiolipin Antibody(aCL) in Abortion Population

作　　者：高阳[1] 宋阳[1] 陈陆[1] 李英 翟燕红[1] GAO Yang;SONG Yang;CHENG Lu(Clinical Laboratory,Beijing Dbstetrics and Gynecology Hospital affiliated to Capital Medical University,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院检验科,北京100026

出　　处：《中国实验诊断学》2018年第7期1205-1208,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨人细小病毒B19抗体及抗心磷脂抗体(aCL)在流产人群中的检测价值,为流产的预防提供理论依据。方法本研究观察对象为2015年1月-2017年1月于我院妇产科就诊的386例自然流产患者以及年龄配对的200例自愿终止妊娠的孕产妇,分别设为观察组与对照组。抽取空腹肘静脉血4ml,离心分析血清后采用酶联免疫吸附试验(ELISA)检测两组孕产妇血清aCLIgG、aCLIgM水平和B19IgG、B19IgM水平,比较两组孕产妇B19IgG、B19IgM、aCLIgG、aCLIgM阳性率以及血清平均水平。结果观察组B19IgG、B19IgM、aCLIgG、aCLIgM阳性率分别为5.08%、41.71%、52.33%、55.44%,对照组分别为6.00%、11.00%、7.00%、7.00%,观察组均显著高于对照组,差异具有统计学意义(P<0.05);观察组血清B19IgG、B19IgM、aCLIgG、aCLIgM水平分别为(1.65±0.23)U/mL、(1.76±0.27)U/mL、(4.54±0.23)U/mL、(22.43±3.32)U/mL,对照组分别为(0.67±0.12)U/mL、(0.54±0.15)U/mL、(2.34±0.15)U/mL、(6.51±1.02)U/mL,观察组均显著高于对照组,差异具有统计学意义(P<0.05)。结论自然流产孕产妇B19抗体、aCL抗体水平均显著高于正常孕产妇,提示其可能参与孕产妇流产的发生,动态监测B19抗体、aCL抗体水平对自然流产的预防具有十分重要的意义。Objective To investigate the detection value of human parvovirus B19 antibody and anticardiolipin antibody（aCL）in abortion population,and to provide a theoretical basis for the prevention of abortion.Methods IN this study,386 cases of spontaneous abortion treated in obstetrics and gynecology department of our hospital from January2015 to January 2017 and 200 age-matched pregnant women received the induced abortion were selected and divided into observation group and control group respectively.The levels of aCLIgG and aCLIgM in the venous blood of the two groups were detected by ELISA,and the levels of B19 IgG and B19 IgM were detected by ELISA.Then the positive rates of B19 IgG,B19 IgM,aCLIgG and aCLIgM,and the mean serum levels of the two groups were compared.Results The positive rates of B19 IgG,B19 IgM,aCLIgG and aCLIgM were 5.08%,41.71%,52.33% and 55.44%in the observation group,which were significantly higher than 6.00%,11.00%,7.00%,7.00%in the control group（P〈0.05）;The levels of B19 IgG,B19 IgM,aCLIgG and aCLIgM were（1.65±0.23）U/mL,（1.76±0.27）U/mL,（4.54±0.23）U/mL and（22.43±3.32）U/mL in the observation group,which were significantly higher than those in the control group[（0.67±0.12）U/mL,（0.54±0.15）U/mL,（2.34±0.15）U/mL and（6.51±1.02）U/mL;（P〈0.05）].Conclusion The levels of B19 antibody and anticardiolipin antibody（aCL）in abortion population are significantly higher than those in the normal women,suggesting that the two indexes may be involved into the abortion occurrence,so the dynamic monitoring of B19 antibody,aCL antibody levels on the prevention of spontaneous abortion is of great significance.

关 键 词：B19 ACL 流产人群 检测价值 

分 类 号：R446.62[医药卫生—诊断学]