阿尔茨海默病患者的内隐记忆启动效应研究  

The study on the implicit memory in patients with Alzheimer disease

作　　者：郭翠萍[1] 白青科[1] 龚亮[2] 赵振国[1] 汪凯[2] GUO Cuiping;BAI Qingke;GONGLiang;ZHAO Zhenguo;WANG Kai(Department of Neurologyf the People Hospital o f Pudong New Area,Shanghai China,201200.)

机构地区：[1]上海市浦东新区人民医院神经内科,上海201200 [2]安徽医科大学神经心理学研究所

出　　处：《中国神经精神疾病杂志》2018年第4期198-200,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市浦东新区卫计委重点学科(编号:PWZxq2017-02);上海市健康医学院种子基金(编号:SFP-18-22-13-004)

摘　　要：目的探讨阿尔茨海默病患者(Alzheimer disease,AD)内隐记忆概念性启动和知觉性启动损害的特征。方法采用分类产生和图片辨别对30例aMCI患者、30例AD和30名正常老年人的内隐记忆(概念性启动和知觉性启动)进行测试,同时进行神经心理学测试(DS、VFT、CTT干扰时间),并进行组间比较和分析。结果与正常老年组、aMCI相比,AD患者组DS、VFT、CTT干扰时间及概念性启动成绩均差于正常对照组(P<0.01);而知觉性启动成绩差异无统计学意义(P>0.05)。结论 AD患者DS、VFT、CTT干扰时间及内隐记忆概念性启动存在损害,提示与AD患者的额叶功能减退可能有关,并且内隐记忆概念启动损害,为早期发现AD患者提供一个新依据。Objective To explore the characteristics of conceptual priming and perceptual priming in patients with Alzheimer＇s disease（AD）. Methods The implicit memory（conceptual repetition priming and perceptual repetition priming） and Neuropsychological（DS, VFT, CTT interference time） tests were conducted on 30 aMCI patients, 30 AD patients and 30 normal elderly people. Results Compared with the normal elderly group and the aMCI group, DS, VFT,CTT interference time and conceptual repetition priming of AD patients were lower than those in the normal elderly group（P〈0.01）. However, perceptual repetition priming was no statistically significant among the groups（P〈0.05）.Conclusion AD patients have impairments on the conceptual repetition priming, DS, VFT, CTT interference time and implicit memory and the decrease in the frontal lobe function may be an important neurological basis for AD.

关 键 词：阿尔茨海默病 内隐记忆 神经心理学 额叶 

分 类 号：R749.16[医药卫生—神经病学与精神病学]