儿童血清25-羟基维生素D_3水平及其与支气管哮喘的关系  

Relation between serum 25-hydroxyvitamin D_3 level and bronchial asthma in children

作　　者：潘秀花[1] 李小妹[1] 黄子殷[1] 庞夏玲 陈南英 吴葆宁[1] 覃敏[1] 佘尚扬[1] 李昌业[1] PAN Xiu-hua;LI Xiao-mei;HUANG Zi-yin;PANG Xia-ling;CHEN Nan-ying;WU Bao-ning;QIN Min;SHE Shang-yang;LI Chang-ye(Department of Pediatrics,the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning 530003,Chin)

机构地区：[1]广西壮族自治区妇幼保健院儿科,南宁市530003

出　　处：《广西医学》2018年第10期1149-1151,共3页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(Z2014149)

摘　　要：目的探讨儿童血清25-羟基维生素D_3水平及其与支气管哮喘的关系。方法选择支气管哮喘患儿103例,其中轻度哮喘35例,重度哮喘68例,按随机数字表法分为哮喘Ⅰ组52例和哮喘Ⅱ组51例。并选取健康儿童60例为对照组。两组哮喘患儿均给予规范化治疗,哮喘Ⅰ组加用维生素D治疗。比较对照组与不同严重度哮喘患儿、哮喘Ⅰ组与哮喘Ⅱ组患儿治疗前后血清25-OH-D_3水平,以及两组哮喘患儿的哮喘控制率、症状缓解所需时间、治疗后1年哮喘复发率。结果血清25-OH-D_3水平呈对照组>轻度哮喘患儿>重度哮喘患儿(P<0.05)。治疗后,哮喘Ⅰ组与哮喘Ⅱ组血清25-OH-D_3水平均高于治疗前,且哮喘Ⅰ组血清25-OH-D_3水平高于哮喘Ⅱ组(均P<0.05);治疗后两组哮喘患儿哮喘控制率均为100.0%,但哮喘Ⅰ组的症状缓解所需时间、哮喘复发率均短于或低于哮喘Ⅱ组(均P<0.05)。结论支气管哮喘患儿血清25-OH-D_3水平降低,且病情越重25-OH-D_3水平越低。辅以维生素D治疗可加速哮喘患儿症状缓解,缩短治疗时间,减少哮喘复发。Objective To explore the relation between serum 25-hydroxyvitamin D3（ 25-OH-D3） level and bronchial asthma in children. Methods A total of 103 children with bronchial asthma,including 35 children with mild asthma and 68 children with severe asthma,were divided into asthma group Ⅰ（ n = 52） and asthma group Ⅱ（ n = 51） using the random number table method. And 60 healthy children were selected as control group. All children with bronchial asthma received standardized treatment,and the children of asthma group Ⅰ were also treated with vitamin D. The serum 25-OH-D3 level before and after treatment were compared among the control group and the children with asthma of different degrees,or between the asthma group Ⅰ and the asthma groupⅡ. The control rate of asthma,the duration for symptoms remission and the recrudescence rate of asthma after 1 year of treatment were compared between the two asthma groups. Results The serum 25-OH-D3 levels decreased in the order of the control group,the children with mild asthma and the children with severe asthma（ P〈0. 05）. After treatment,the serum 25-OH-D3 levels decreased in the asthma group Ⅰ and asthma group Ⅱ,and the level of the asthma group Ⅰ was higher than that of the asthma group Ⅱ（ all P〈0. 05）. After treatment,the control rate of asthma was100. 0% in the two asthma groups. The duration for symptoms remission and the recrudescence rate of asthma in the asthma group Ⅰ were less or lower than those in the asthma group Ⅱ（ all P〈0. 05）. Conclusion Serum 25-OH-D3 level decreases in the children with bronchial asthma,and is less in the children with more severe asthma. Adjunctive therapy of vitamin D can accelerate the symptom remission,decrease the duration for treatment and reduce the recurrence of asthma.

关 键 词：支气管哮喘 25-羟基维生素D 儿童 

分 类 号：R725.622.5[医药卫生—儿科]