糖尿病勃起功能障碍患病因素分析及降糖干预评价  

Analysis of Prevalence Factor of Patients with Diabetes-induced Erectile Dysfunction and Evaluation on the Hypoglycemic Intervention

作　　者：张培[1] 赵士凯[2] 赵守国[2] 刘玉[1] ZHANG Pei;ZHAO Shi-kai;ZHAO Shou-guo;LIU Yu(Department of Endocrinology,Liaocheng People＇s Hospital,Liaocheng,Shandong Province,252000 China;Department of Andrology,Liaocheng People＇ s Hospital,Liaocheng,Shandong Province,252000 China)

机构地区：[1]聊城市人民医院内分泌科,山东聊城252000 [2]聊城市人民医院男科,山东聊城252000

出　　处：《中外医疗》2018年第11期32-35,共4页China & Foreign Medical Treatment

摘　　要：目的探讨影响中青年2型糖尿病患者勃起功能的因素,观察降糖治疗对勃起功能障碍(ED)的改善效果。方法随机选择2014年7月—2015年7月聊城市人民医院男科及内分泌科门诊男性糖尿病患者104例作为研究对象,均为中青年2型糖尿病已婚男性患者,利用无记名问卷[根据国际勃起功能指数表(IIEF-5)]调查,判断其有无ED,分为ED组(n=77例)与非ED组(n=27例),对比分析两组患者的糖尿病病程、空腹血糖(FBG)、餐后2 h血糖(PBG2 h)、糖化血红蛋白(Hb A1c)对ED的影响,并记录血脂(总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-c))、年龄、吸烟、饮酒、体重指数(BMI)、血压、阴茎血流指数(PFI)、总睾酮(TT)等指标。对部分患者进行降糖干预,对比降糖治疗前后IIEF-5评分、夜间阴茎勃起功能监测(NPT)、PFI、血糖等的变化。结果两组间BMI、TT、TC均值比较差异无统计学意义[依次为(25.926±2.246 1)kg/m2vs(26.730±3.286 3)kg/m2,(4.061 1±1.226 2)ng/m L vs(3.638 1±0.749 96)ng/m L,(4.435±1.261 7)mmol/L vs(5.790±1.741 1)mmol/L,t=1.771、1.491、1.205,P>0.05],SBP、FBG、PBG2 h、LDL-C、PFI、Hb A1c均值对比差异有统计学意义[依次为(128.52±8.833)mm Hg vs(138.49±14.636)mm Hg,(6.623±1.186 2)mmol/L vs(7.613±1.776 6)mmol/L,(9.574±2.793 2)mmol/L vs(12.651±4.296 8)mmol/L,(2.490 7±1.059 2)mmol/L vs(3.875 2±1.580 79)mmol/L,(3.859±0.937 0)vs(5.566±1.975 2),(6.978±2.073 3)%vs(10.290±3.537 8)%,t=3.327、2.688、5.215、4.224、4.313、4.587,P<0.05];给予胰岛素降糖治疗3个月后,IIEF-5评分、FBG、PBG2 h、Hb A1c、PFI均值与治疗前相比,差异有统计学意义[(5.97±4.043)vs(15.79±2.459),(8.567±1.827 9)mmol/L vs(6.764±0.951 9)mmol/L,(15.352±4.157 8)mmol/L vs(10.303±1.712 7)mmol/L,(13.697±2.539 9)%vs(7.645±0.845 6)%,(6.391±2.189 7)vs(4.958±1.472 9),t=11.921、5.026、3.337、6.450、6.118,P<0.05],IIEF-5评分与BMI、TC、TT、收缩压相关差异无统计学意义(P>0.05)。结论中青年2型Objective To study the prevalence factor of patients with diabetes-induced erectile dysfunction and evaluation on the hypoglycemic intervention. Methods 104 cases of outpatient male patients with diabetes in our hospital from July2014 to July 2015 were selected, the patients were surveyed by the secret questionnaire（according to the IIEF-5）, and ED or not was determined, and the patients were divided into the ED group with 77 cases and non-ED group with 27 cases,and the effect of diabetic course treatment, FBG, PBG2 h and Hb A1 c on ED was analyzed and compared, and the TC, TG,LDL-c, age, smoking, alcohol, drinking, BMI, blood pressure, PFI and TT were recorded, and some patients were for hypoglycemic intervention, and the IIEF-5 score, NPT, PFI and blood glucose changes before and after the hypoglycemic treatment were compared. Results The differences in the BMI,TT,TC values between the two groups were not statistically significant[（25.926±2.246 1）kg/m2 vs（26.730±3.286 3）kg/m2,（4.061 1±1.226 2）ng/m L vs（3.638 1±0.749 96）ng/m L,（4.435±1.261 7）mmol/L vs（5.790±1.741 1）mmol/L,t=1.771,1.491,1.205,P〉0.05],and the differences in the SBP, FBG, PBG2 h, LDL-C, PFI,Hb A1 c between the two groups were statistically significant[（128.52±8.833）mm Hg vs（138.49±14.636）mm Hg,（6.623±1.186 2）mmol/L vs（7.613±1.776 6）mmol/L,（9.574±2.793 2）mmol/L vs（12.651±4.296 8）mmol/L,（2.490 7±1.059 2）mmol/L vs（3.875 2±1.580 79）mmol/L,（3.859 ±0.937 0） vs（5.566 ±1.975 2）,（6.978 ±2.073 3）% vs（10.290 ±3.537 8）%,t =3.327,2.688, 5.215,4.224,4.313,4.587,P〈0.05],after three months, the differences in the IIEF-5,FBG,PBG2 h,Hb A1 c,PFI average values before and after treatment were obvious[（5.97±4.043） vs（15.79±2.459）,（8.567±1.827 9）mmol/L vs（6.764±0.951 9）mmol/L,（15.352±4.157 8）mmol/L vs（10.303±1.712 7）mmol/L,（13.697±2.539 9）% vs（7.645±0.845 6）%,（6.391±2.189 7） vs（4.958±1.472 9）,t=11.921,5.026,3.337,6.450,6.118

关 键 词：勃起功能障碍 糖尿病 2型 中青年 影响因素 

分 类 号：R4[医药卫生—临床医学]