不同容量的连续性血液滤过治疗难治性心衰患者的临床疗效及对神经内分泌因子的影响  

Clinical Curative Effect of Different Capacities of Continuous Hemofiltration in Treatment of Patients with Refractory Heart Failure and Effect on the Neuroendocrine Factors

作　　者：赵红艳 张琳 ZHAO Hong-yan;ZHANG Lin(ICU,Third Affiliated Hospital of Medical University Of Anhui,Hefei,Anhui Province,230000 Chin)

机构地区：[1]安徽医科大学第三附属医院重症监护室,安徽合肥230000

出　　处：《中外医疗》2018年第11期46-48,共3页China & Foreign Medical Treatment

摘　　要：目的观察不同容量持续性血液滤过治疗难治性心衰患者临床疗效及对血清神经内分泌因子的影响。方法方便选取该院2014年6月—2016年6月难治性心衰患者98例,将98例患者随机分为低容量滤过组(A组)及高容量滤过组(B组),比较两组的临床疗效及神经内分泌因子的变化。结果两组患者PRA、AngⅡ、ALD、TNF-α、BNP等神经内分泌因子较治疗前均好转(t=4.336,4.636,4.452,3.553,6.814,P<0.05);B组患者的总有效率明显高于A组(84.8%vs 94.2%),差异有统计学意义(P<0.05)。结论高容量连续性血液滤过对难治性心衰的治疗更有优势。Objective To observe the clinical curative effect of different capacities of continuous hemofiltration in treatment of patients with refractory heart failure and effect on the neuroendocrine factors. Methods 98 cases of patients with refractory heart failure admitted and treated in our hospital from June 2014 to June 2016 were convenient selected and randomly divided into two groups, the group A were the low capacity filtration patients, and the group B were the high capacity filtration patients, and the changes of clinical curative effect and neuroendocrine factors were compared between the two groups.Results The neuroendocrine factors such as PRA, Ang, ALD, TNF-α, BNP of the two groups were improved（t =4.336,4.636,4.452,3.553,6.814, P〈0.05）, and the total effective rate in the group B was obviously higher than that in the group A（84.8% vs 94.2%）, and the difference between the two groups was statistically significant（P〈0.05）. Conclusion The treatment of high capacity continuous hemofiltration in treatment of patients with refractory heart failure is advantageous.

关 键 词：血液滤过 难治性 心衰 神经内分泌因子 

分 类 号：R5[医药卫生—内科学]