胆红素的光学检测方法研究进展  

Development of Optical Detection Methods for Bilirubin

作　　者：付笛 张子建 徐亭晚 邓小峰[2] 陈丹 刑扬 姚兴旺[2] 李雅湘 苗雄鹰[2] 李清龙[2] 文宇[2] 熊力[2] FU Di;ZHANG Zijian;XU Tingwan;DENG Xiaofeng;CHEN Dan;XING Yang;YAO Xingwang;LI Yaxiang;MIAO Xiongying;LI Qinglong;WEN Yu;XIONG Li(The Third Xiangya Hospital of Central South University,Changsha 410012,Hunan,China;The Second Xiangya Hospital of Central South University,Changsha 410011,Hunan,China;Xiangya School of Medicine,Central South University,Changsha 410012,Hunan,China;Zhuhai People＇ s Hospital,Zhuhai 519000,Guangdong,China)

机构地区：[1]中南大学湘雅三医院,湖南长沙410012 [2]中南大学湘雅二医院,湖南长沙410011 [3]中南大学湘雅医学院,湖南长沙410012 [4]珠海市人民医院,广东珠海519000

出　　处：《激光生物学报》2018年第3期205-210,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金面上项目(81773293);湖南省重点研发计划-实验动物重点研发项目(2017DK2011);湖南省重点研发计划-国际与区域科技创新合作重点研发项目(2017WK2060);湖南省科技厅技术创新引导计划重点项目(2015GK3117);珠海市科技计划(2015A0025)

摘　　要：黄疸是一种临床上常见的症状和体征,为血液胆红素升高所致。血液中胆红素升高不仅提示可能存在严重的原发病,而且过高的胆红素还可能导致胆红素脑病,重者导致死亡。临床上可早期应用光学方法在人群中进行无创筛查,对筛查阳性患者再进行血液检查进行诊断,从而增加黄疸及其相关疾病的发现概率。本文就近几年胆红素的光学检测方法的研究进展予以综述。Jaundice is a clinically common symptonl and sign, which is caused by elevated blood bilirubin. Elevated levels of bilirubin in the blood not only indicate that there may be a severe primary disease, but that excessive bilirubin may also cause bilirubin encephalopathy, which in severe cases leads to death. Clinically, non-invasive screening can be performed early in the population using optical methods, and blood screening for positive screening patients can be per- formed for diagnosis, thereby increasing the probability- of finding jaundice and related diseases. This article reviews the research progress of optical detection methods for bilirubin in recent years.

关 键 词：胆红素 光学检测 研究进展 

分 类 号：R446.1[医药卫生—诊断学]