IVF双卵三胎1例报道  

Acasereport ofthree embryos within two oospermsin in-vitro fertilization

作　　者：王天琪[1] 孙振高[2] 杨毅[1] 王晓明[1] 徐凯月 宋景艳 张兴兴[1] 王爱娟[1] 苑丽华[1] 姜华颖[1] 撒元红 肖继梅 FANG Tianqil;SUN Zhengao;YANG Yi;WANG Xiaoming;XU Kaiyue;SONG Jingyan;ZHANG Xingxing;WANG Aijuan;YUAN Lihua;JIANG Huaying;XIAO Jimei(Shandong University of Traditional Chinese Medicine Jinan250011,Shandong,China;Center for Reproduction andGeneticslntegrated Traditional Chinese and Western Medicine,The Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Jinan250014,Shandong,China)

机构地区：[1]山东中医药大学妇科,济南250014 [2]山东中医药大学附属医院中西医结合生殖与遗传中心,济南250014

出　　处：《中国性科学》2018年第5期100-102,共3页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金项目(81373676;81674018)

摘　　要：体外受精-胚胎移植(IVF-ET)作为现代辅助生育技术(ART)的代表,在不孕不育病症的治疗中起着举足轻重的作用。但该技术在助孕过程中,多胎妊娠率也随之增加,有关研究结果显示,IVF-ET周期中双胎妊娠率为29%,三胎妊娠为3.7%,分别是自然妊娠的14倍和54倍^([1])。其中,单卵双胎的发生率增加直接导致了双卵三胎的概率也比自然妊娠高^([2-4]),双卵三胎形成的具体机制尚不明确,现认为可能与控制性超促排卵(COH)、卵母细胞透明带显微操作及体外培养微环境、囊胚移植等因素相关。近期山东中医药大学附属医院中西医结合生殖与遗传中心发现IVF双卵三胎1例。In vitro fertilization-embryo transfer（ IVF-ET）,as a representative of modern assisted reproductive technology（ ART）,plays an important role in the treatment of infertility. But the incidence of multiple pregnancy in the IVF-ET is high. According to statistics,the incidence of gemellary pregnancy and triplet pregnancy was 29% and 3. 7% respectively,14 times and 54 times of the natural pregnancy rate accordingly^（[1]）. The increase in the incidence of monozygotic twins directly led to the increased probability of three embryos within two oosperms,which was higher than the natural pregnancy^（[2-4]）. Though the formation mechanism was not clear,influencing factors might include controlled ovulation（ COH）,oocyte microcirculation and microenvironment,blastocyst transplantation and others.

关 键 词：体外受精-胚胎移植 多胎妊娠 双卵三胎 

分 类 号：R714.8[医药卫生—妇产科学]