尖锐湿疣复发患者HPV基因分型的分布情况及关系分析  

Distribution of HPV genotypes and their relationships in patients with recurrent condyloma acuminatum

作　　者：景伟芳[1] 周娜娜[1] 刘雪[1] 尹鸿英 王敬茶 JING Weifang;ZHOU Nana;LIU Xue;YIN Hongying;FANG Jingcha(Department of Dermatology,Central Hospi- tal of China National Petroleum Corporation,Langfang 065000,Hebei,Chin)

机构地区：[1]中国石油天然气集团公司中心医院皮肤科,河北廊坊065000

出　　处：《中国性科学》2018年第5期114-117,共4页Chinese Journal of Human Sexuality

摘　　要：目的:研究尖锐湿疣复发患者人乳头瘤病毒(HPV)基因分型的分布情况及关系。方法:选取中国石油天然气集团公司中心医院2014年10月至2016年10月285例尖锐湿疣复发患者为研究对象,采集尖锐湿疣组织样本,进行HPV基因分型检测。结果:271例HPV阳性尖锐湿疣复发患者低危型HPV感染率为37.6%,高危型HPV感染率为84.5%,单一型HPV感染率为53.9%,复合型HPV感染率为46.1%。HPV16与HPV18感染率分别为36.9%、32.1%。尖锐湿疣复发患者低危型HPV感染比例显著高于高危型HPV感染(P<0.05)。结论:高危型HPV基因是尖锐湿疣复发患者HPV感染主要类型,其中HPV16与HPV18为尖锐湿疣复发患者最常见HPV基因亚型。Objective： To investigate the distribution of human papilloma virus（ HPV） genotypes and their relationships in patients with recurrent condyloma acuminatum（ CA）. Methods： 285 patients with recurrent CA treated in the Central Hospital of China National Petroleum Corporation from October 2014 to October 2016 were selected as the study subjects. The CA samples were collected and HPV genotype was detected. Results： In the 271 patients with HPV positive recurrent CA,the rates of low-risk HPV infection,high-risk HPV infection,single HPV infection and mixed HPV infection were 37. 6%,84. 5%,53. 9% and 46. 1% respectively. The rates of HPV16 and HPV18 infections were 36. 9% and 32. 1% respectively. The rate of low-risk HPV infection was higher than that of high-risk HPV infection in patients with recurrent CA（ P〈0. 05）. Conclusions： High-risk HPV genotype is the main type of HPV infection in patients with recurrent CA,where HPV16 and HPV18 are the most common subtypes.

关 键 词：尖锐湿疣 复发 人乳头瘤病毒 基因分型 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]