Lingo-1及其相关传导通路在神经系统修复中的研究进展  

Research progresses on Lingo -1 and its related conductive pathway for nervous system repair

作　　者：王天双 肖刚[2] 李林[1] 张俭[1] 张德新[1] 陆莹[1] Wang Tian-shuang;Xiao Gang;Li Lin;Zhang Jian;Zhang De-xin;Lu Ying(Department of Emergency,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086 [2]中国人民解放军第二一一医院,黑龙江哈尔滨150080

出　　处：《中国急救医学》2018年第7期636-640,共5页Chinese Journal of Critical Care Medicine

基　　金：黑龙江省自然科学基金面上项目（H201422）

摘　　要：富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1（Lingo-1）在神经元与少突胶质细胞修复、神经突延长、轴突再生等过程中，通过NgR/p75/Lingo-1或NgR/TROY/Lingo-1、WNK1、Myt1与Myt1l等通路发挥明确的负性调节作用，阻断Lingo-1及其通路可促进损伤的中枢神经系统再生，提示Lingo-1有可能成为治疗神经精神系统疾病的新靶点。Leucine- rich repeat and Ig domain -containing, nogo receptorinteracting protein- 1 （ Lingo - 1 ） has a definite negative regulating effect through the pathways of NgR/p75 / lingo - 1 or NgR/TROY/lingo-1, WNK1, Mytl and Mytll during neuronal and oligodendrocyte repair, neurite extension, axon regeneration, etc. Blocking Lingo - 1 and its pathway can promote the regeneration of damaged central nervous system, suggesting that lingo - 1 may become a new target for treatment and neuropsychiatric diseases.

关 键 词：富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1(Lingo-1) 中枢神经系统损伤 神经再生 传导通路 

分 类 号：R651[医药卫生—外科学]