通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺（英文）  

Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

作　　者：谭家希 郭也 曾飞[1] 陈观荣 谢龙勇 何卫民[1] Tan Jiaxi;Guo Ye;Zeng Fei;Chen Guanrong;Xie Longyong;He Weimin(Hunan Provincial Engineering Research Center for Ginkgo biloba,Hunan University of Science and Engineering,Yongzhou 425100)

机构地区：[1]湖南省银杏工程技术研究中心湖南科技学院,永州425100

出　　处：《有机化学》2018年第7期1740-1748,共9页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.21602055,21302048);the Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province(No.2012-318);the Construct Program of the Key Discipline in Hunan Province~~

摘　　要：以商业可获得的羧酸和异硫氰酸酯为原料,建立了一种温和、通用、高效的直接合成酰胺化合物的新方法.该方法避免了当量偶联试剂和金属催化剂的使用,特别适合于合成其他常规方法不易合成的大位阻和缺电子仲酰胺化合物.A mild, general and efficient method for the direct synthesis of diverse amides from commercially available carboxylic acids and isothiocyanates has been developed. The strategy does not require stoichiometric amounts of coupling rea- gents or metal catalysts, and is especially for sterically hindered and electron-deficient secondary amides, which are otherwise challenging to synthesize.

关 键 词：酰胺 羧酸 异硫氰酸酯 合成方法学 缺电子酰胺 

分 类 号：O623.626[理学—有机化学]