微量泵补钾与传统补钾在连续性肾脏替代治疗中的应用效果比较  

Comparison of potassium supplement with infusion pump and traditional potassium supplement in continuous renal replacement therapy

作　　者：陈志文[1] 唐晓娟[1] 王蓓蓓[1] 张胜[1] 魏甜甜 代明金[1] CHEN Zhiwen;TANG Xiaojuan;WANG Beibei;ZHANG Sheng;WEI Tiantian;DAI Mingjin(Department of Nephrology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院肾脏内科,成都610041

出　　处：《华西医学》2018年第7期856-859,共4页West China Medical Journal

基　　金：中华医学会青年基金(13030330418)

摘　　要：目的探讨微量泵补钾在连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)患者治疗中的可行性及应用效果。方法 2018年3月—5月纳入行CRRT的危重症患者,并随机分为微量泵组和传统补钾组。治疗过程中,微量泵组使用微量泵入10%氯化钾,传统补钾组采用传统的加10%氯化钾入置换液的方式补钾,通过测定两组患者CRRT治疗前(0 h)和治疗后2、8、12、24 h外周血钾水平、血钾控制达标率、不良事件发生率、平均更换液袋次数、平均停泵时间、达成剂量和实际补钾量比较两组加钾方式的应用效果。结果共纳入60例患者,两组各30例。两组患者CRRT治疗前(0 h)和治疗后2、8、12、24 h外周血钾水平、血钾控制达标率和达成剂量差异均无统计学意义(P>0.05);不良事件发生率、平均更换液袋次数、平均停泵时间和实际补钾量差异均有统计学意义(P<0.05)。结论微量泵补钾在CRRT患者治疗中的应用具备可行性及安全性,且较传统补钾方式更具优势,可在临床进一步推广应用。Objective To explore the feasibility and effect of infusion pump potassium supplementation in continuous renal replacement therapy（CRRT）. Methods Patients who underwent CRRT were randomly divided into infusion pump group and traditional way group between March and May 2018. In infusion pump group, 10% potassium chloride was supplemented with infusion pump. In traditional way group, 10% potassium chloride was supplemented in the traditional way, which meant adding potassium in the replacement solution. The peripheral blood potassium level, the potassium well-controlled rate, the incidence of adverse events, the average frequency of replacement liquid bags change,the average pump stopping time, and the delivery dose and potassium supplement dose between the two groups were compared. Results A total of 60 patients were randomly divided into two groups, with 30 cases in each group. The infusion pump group was treated with an average of 6.90 mL/h potassium supplement dose by infusion pump, and in traditional way group, potassium was added to the replacement solution by an average of 9.29 mL/h; there were significant differences between the two groups（P〈0.05）. When compared with traditional way group, there was no significant differences（P〉0.05） in the peripheral blood potassium level and the potassium well-controlled rate of the patients at 0, 2,8, 12 and 24 hours after CRRT（P〈0.05）. As for the adverse events rate, average frequency of replacement liquid bags change, average pump stopping time, and potassium supplement dose, there were significant differences between the two groups（P〈0.05）. Conclusions The application of infusion pump to supply potassium in CRRT is feasible and safe, and is superior to the traditional potassium supplement method. It could be further applied in clinical practice.

关 键 词：连续性肾脏替代治疗 微量泵 氯化钾 

分 类 号：R692[医药卫生—泌尿科学]