血清IL-10水平与内源性分泌型糖化终末产物受体比值对宁夏地区回、汉族2型糖尿病合并冠状动脉弥漫性病变的对比研究  

A study on serum IL-10 level and endogenous secretory end product receptor ratio with diffuse coronary artery disease in Ningxia Hui and Han patients with type 2 diabetes mellitus

作　　者：金学林[1] 李虎宁 马伟 赵晓燕[3] 吴波[3] 张文斌 姜培培[3] JIN Xnelin;LI Huning;MA Wei;ZHAO Xiaoyan;WU Bo;ZHANG Wenbin;JIANGPeipei(Department of Cardiology,The First People＇s Hospitalof Shizuishan,Shizuishan 753200,China;The pharmacy division of shizuishan first People＇s hospital.Shizuishan 753200,China;Department of cardiaology medicine,the fifth Hospital of PIA,Yinchuan 750004,China)

机构地区：[1]宁夏石嘴山市第一人民医院心内科,宁夏石嘴山753200 [2]宁夏石嘴山市第一人民医院药剂科,宁夏石嘴山753200 [3]解放军第五医院心内科,宁夏银川750004

出　　处：《宁夏医学杂志》2018年第6期498-500,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ16241)

摘　　要：目的探讨IL-10与内源性分泌型糖化终末产物受体(esRAGE)比值与宁夏地区回、汉族2型糖尿病合并冠状动脉弥漫性病变的关系。方法选择340例糖尿病患者行冠状动脉(冠脉)造影检查,其中回、汉族糖尿病冠状动脉弥漫性病变组各100例。选择非糖尿病冠状动脉弥漫性病变140例作为对照组研究,比较回、汉组组间IL-10与esRAGE比值的变化水平。结果回族糖尿病冠状动脉弥漫性病变组较汉族组IL-10[(34.33±2.00)比(25.42±2.02)pg/mL]及IL-10/esRAGE[(184.68±23.070)比(107.995±11.494)]明显升高(P<0.05);而esRAGE[(0.188±0.019)比(0.237±0.019)ng/mL]比较明显降低(P<0.05);进一步研究发现,糖尿病冠状动脉弥漫性病变组与糖尿病冠状动脉非弥漫性病变组IL-10[(29.24±4.929)比(20.31±2.950)pg/mL]及L-10/esRAGE[(140.86±42.39)比(90.789±16.607)]显著升高(P<0.05);而esRAGE差异无统计学意义(P>0.05)。结论 IL-10水平与内源性分泌型糖化终末产物受体比值在宁夏地区回族2型糖尿病合并冠状动脉弥漫性病变患者发病中具有重要作用。Objective To explore the association ofserum IL-10 level and endogenous secretory end product receptor ratio with diffuse coronary artery disease in patients with type 2 diabetes mellitus in Ningxia between Hui and Han Nationality. Methods Among340 consecutive patients with coronary heart disease and type2 diabetes mellitus,100 Hui Nationality patients were diffuse coronary artery disease（Group I）,and 100 Han Nationality patientswere diffuse coronary artery disease（Group II）. Another 140 patients with NON diffuse coronary artery disease with diabetes were served as a control group. The changes of the levels of IL-10,endogenous secretory end product receptor and IL-10 level and endogenous secretory end product receptor ratio in the two groups were compared. Serum levels of Serum levels of IL-10 and endogenous secretory end product receptorwere measured using ILISA methods. Results IL-10,IL-10 and endogenous secretory end product receptor ratio levels were significantly higher in Group I than that incontrol group. IL-10（34. 33 ± 2. 00） was higherin Group I than that in Group II（25. 42 ± 2. 02） pg/mL〗and IL-10/esRAGE（184. 68 ± 23. 070） was higher in Group I than that in Group II（107. 995 ± 11. 494）（P〈0.05）,and was inversely related to esRAGE levels. Further analyzed the levels of IL-10 and IL-10/esRAGE ratio levels increased significantly in diffuse coronary artery disease with type 2 diabetes mellitus than that of control group（P〈0.05）,was not related to esRAGE level. Conclusion IL-10 and IL-10/esRAGE ratio levels may play an important role in the Hui Nationality patients diffuse coronary artery diseasewith type 2 diabetes mellitus in Ningxia.

关 键 词：内源性分泌型糖化终末产物受体 IL-10 2型糖尿病 冠状动脉弥漫性病变 心血管造影 

分 类 号：R587.1[医药卫生—内分泌]