经尿道切除术联合术后吡柔比星灌注对腺性膀胱炎患者尿道动力学及血清SAA、CRP、IL-6、TNF-α水平的影响  

Effect of transurethral resection combined with postoperative pirarubicin instillation on urethral dynamics and SAA, CRP, IL-6 and TNF-α serum levels in patients with glandular cystitis

作　　者：周黎强 余春慧 ZHOU Li-qiang;YU Chun-hui(the Hospital of Chenggu County,Hanzhong 723000,Chin)

机构地区：[1]城固县医院,陕西汉中723000

出　　处：《临床医学研究与实践》2018年第16期57-58,共2页Clinical Research and Practice

摘　　要：目的探讨经尿道切除术联合术后吡柔比星灌注对腺性膀胱炎患者尿道动力学及血清SAA、CRP、IL-6、TNF-α水平的影响。方法收集我院就诊的腺性膀胱炎患者114例,按照临床治疗方案的不同分为对照组和试验组,每组57例。两组患者均行经尿道切除术治疗,仅试验组联合术后吡柔比星灌注治疗。统计并比较治疗前、后两组患者的尿道动力学、血清SAA、CRP、IL-6、TNF-α水平。结果治疗后,两组最大尿流率和平均尿流率明显升高,且试验组明显高于对照组(P<0.05);两组最大尿道压明显降低,且试验组明显低于对照组(P<0.05)。与治疗前和治疗1 d后比较,两组患者在治疗后1个月、3个月时血清SAA、CRP、IL-6、TNF-α水平均出现显著下降,且试验组明显低于对照组(P<0.05)。结论腺性膀胱炎患者经尿道切除术联合术后吡柔比星灌注治疗后,尿道动力学和血清炎性因子水平均得到一定改善。经尿道切除术联合术后吡柔比星灌注对腺性膀胱炎疗效确切,具有一定的临床应用价值。Objective To evaluate the effect of transurethral resection combined with postoperative pirarubicin instillation on urethral dynamics and serum SAA, CRP, IL-6, TNF-α levels in patients with glandular cystitis. Methods A total of 114 patients with glandular cystitis were collected in our hospital and divided into experiment group and control group by different therapy methods. All the patients were treated by transurethral resection, the experiment group was merely treated by postoperative pirarubicin instillation. The urethral dynamics and serum levels of SAA, CRP, IL-6 and TNF-α before and after treatment were statistical and compared between the two groups. Results After treatment, the maximum urinary flow rate and average urine flow rate significantly increased in both groups, those in the experiment group were significantly higher than the control group（P〈0.05）. The maximum urethral pressure significantly decreased in both groups, that in the experiment group was significantly lower than the control group（P〈0.05）. Compared with before treatment and 1 d after treatment, the serum SAA, CRP, IL-6 and TNF-α levels decreased significantly at 1 month and 3 months after treatment in both groups, those in the experiment group were significantly lower than the control group（P〈0.05）. Conclusion The urethral dynamics and serum inflammatory index of patients with glandular cystitis treated by transurethral resection and postoperative pirarubicin instillation have been improved. The therapy method has exact effect and certain clinical application value.

关 键 词：经尿道切除术 吡柔比星 腺性膀胱炎 膀胱灌注 

分 类 号：R694.3[医药卫生—泌尿科学]