可降解血管支架材料降解行为研究进展  

Research Progress on Degradation Behavior of the Biodegradable Materials for Vascular Stents

作　　者：崔晓珊 周超 张海军 CUI Xiaoshan 1, ZHOU Chao 1, ZHANG Haijun 1,2(1 National United Engineering Laboratory for Biomedical Material Modification Branden Industrial Park, Dezhou 251100;2 Institute of Interventional ＆ Vascular Surgery, Tongji University, Shanghai 20007)

机构地区：[1]生物医用材料改性技术国家地方联合工程实验室,德州251100 [2]同济大学医学院介入血管研究所,上海200072

出　　处：《材料导报》2018年第A01期192-195,共4页Materials Reports

基　　金：国家重点研发计划(2016YFC1102500)

摘　　要：目前可降解血管支架材料包括聚合物、镁合金、铁合金及锌合金,它们的降解特性直接影响其作为血管支架植入后的支撑能力、局部反应和血管修复的预后。聚合物降解时间较易调整、生物相容性较好,但力学性能不足;镁合金的降解存在降解速率快、释氢反应和微环境pH值变化较大的问题;铁合金降解速率太慢;锌合金的降解速率适中,是近年可降解血管内植入材料研究热点。除了材料自身的特性,可降解材料的血管内降解行为还受到环境的离子浓度、酶、pH值和温度等多种因素的影响。综述了目前不同血管内可降解支架材料在模拟体液及动物体内生物降解行为的研究结果,以期为血管内可降解材料研究和产品开发提供参考。The bioresorbable materials of stents include polymer,magnesium-based alloy,iron-based alloy and zinc-based alloy.Degradation properties of these materials directly affect their support capability,local response and long-term vascular repair prognosis after implantation.The polymer has large adjustable degradation time range,good bio-compatibility,but lacks the mechanical property.The problem of magnesium alloy is the fast degradation rate,the release of local hydrogen and relatively large pH variation in micro-environment.On the other side,ferroalloys degrade too slow compared to magnesium alloy.Among all,the performance of zinc alloys seems more appropriate in terms of degradation behavior and corrosion rate.It has become a new promising implantable and biodegradable metallic material for vascular applications in recent years.In addition to its own nature,the degradation behaviors of the bioresorbable material within blood vessel are also influenced by in-vivo factors such as ion concentration,enzyme,pH value and temperature in local environment.This review introduces the corrosion degradation behavior of different materials in simulated body fluids and animal body,providing references for the research and product development of degradable materials in blood vessels.

关 键 词：镁合金 铁合金 锌合金 降解 可降解聚合物 

分 类 号：R318.08[医药卫生—生物医学工程]