血清胱抑素C、尿液肾脏损伤分子1水平对高血压肾小管间质损伤程度的评估意义  

The Significance of Serum Cystatin C and Urine Kidney Injury Molecule 1 Levels in Evaluating Renal Tubule Damage in Patients with Hypertension

作　　者：陈玉平[1] 黄力[1] 伍锦泉[1] CHEN Yuping;HUANG Li;WU JinquanZ(Department of Nephrology,Zhaoqing First People ＇s Hospital,Zhaoqing 526000,Chin)

机构地区：[1]肇庆市第一人民医院肾内科,广东肇庆526000

出　　处：《临床医学工程》2018年第8期1077-1078,共2页Clinical Medicine & Engineering

摘　　要：目的探讨血清Cys C、尿液KIM-1水平对高血压肾小管间质损伤程度的评估意义。方法选取原发性高血压患者85例为高血压组,30例无器质性病变的同期健康查体者为对照组。检测比较两组的血清Cys C、尿液KIM-1、尿NGAL水平,以及SBP、DBP。结果与对照组比较,高血压组患者的SBP、DBP、血清Cys C、尿液KIM-1、尿NGAL水平均升高(P<0.05)。高血压组中,与尿NGAL水平<131.7 ng/m L的患者比较,尿NGAL水平≥131.7 ng/m L患者的SBP、DBP、血清Cys C、尿液KIM-1水平均升高(P<0.05)。高血压患者的血清Cys C水平和尿液KIM-1水平与其SBP、DBP和尿NGAL水平均呈正相关(P<0.05)。结论高血压患者的血清Cys C水平和尿液KIM-1水平与其血压水平和肾小管间质损伤程度密切相关。Objective To investigate the significance of serum Cys C and urine KIM-1 levels in evaluating renal tubule damage in patients with hypertension. Methods 85 cases of patients with primary hypertension were selected as the hypertension group, and 30 cases of healthy subjects with no organic lesion who received physical examination at the same period were selected as the control group. The levels of serum Cys C, urine KIM-1 and NGAL, as well as SBP and DBP of the two groups were detected and compared. Results The levels of SBP, DBP, serum Cys C, and urine KIM-1 and NGAL of the hypertension group were significantly higher than those of the control group（P〈0.05）. In the hypertension group, the levels of SBP, DBP, serum Cys C, and urine KIM-1 of patients with urine NGAL level ≥131.7 ng/m L were significantly higher than those of patients with urine NGAL level 131.7 ng/m L（P〈0.05）. The levels of serum Cys C and urine KIM-1 of hypertension patients were positively correlated with SBP, DBP and urine NGAL levels（P〈0.05）. Conclusions The levels of serum Cys C and urine KIM-1 are closely related to the blood pressure level and degree of renal tubule damage.

关 键 词：胱抑素C 尿液肾脏损伤分子1 高血压 肾小管间质损伤 评估 

分 类 号：R544.1[医药卫生—心血管疾病]