Haliclona属海绵化学成分及生物活性研究新进展  

New Research Progress on Chemical Constituents and Their Bioactivities from Marine Sponges of Genus Haliclona

作　　者：田祥云 何山[1] 丁立建 TIAN Xiang-yun;HE Shan;DING Li-jian(Laboratory of Marine Natural Products in School of Marine Sciences,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学海洋学院海洋天然产物实验室,宁波315211

出　　处：《天然产物研究与开发》2018年第7期1274-1279,共6页Natural Product Research and Development

基　　金：国家自然科学基金(41776168;41706167);宁波大学科研基金(XYL17016)

摘　　要：蜂海绵属(Haliclona)在海洋生态系统中分布较为广泛,从中分离到许多结构新颖的化学成分,包括生物碱、炔类、萜类、甾醇等,其中以生物碱类化合物最为典型,并且大多化学成分有较强生物活性,如细胞毒、抗菌、抗污、抗肿瘤等。本文综述了国内外近10年有关蜂海绵属的化学成分及生物活性的研究,旨在为该属海绵的化学成分和生物活性的进一步研究提供参考。Marine sponges of the genus Haliclona are widely distributed in marine ecosystems. A variety of chemical constituents with novel structures such as alkaloids,peptides,terpenoids,steroids,unsaturated aliphatic hydrocarbons,have been isolated from marine sponge Haliclona. Among them,the most common secondary metabolites of marine sponge Haliclona are alkaloids. In addition,many of secondary metabolites possess a variety of biological activities,such as cytotoxic,antimicrobial,antifouling,antitumor. This paper reviewed the chemical constituents and bioactivities from the sponges of genus Haliclona in recent 10 years,which is intended to provide guidance for the further research of chemical constituents and their bioactivities from the marine sponge Haliclona.

关 键 词：Haliclona sp. 化学成分 生物活性 

分 类 号：Q931.77[生物学—微生物学]