基于微流控液滴形成技术的聚乙烯醇微球制备  

Preparation of Poly (vinyl alcohol) Microspheres Based on Droplet Microfluidic Technology

作　　者：韩县伟 张洪武 罗洪艳[1] 郑小林[1] 杨忠[3] 胡宁[1] 廖彦剑[1] 杨军[1] HAN Xian-Wei;ZHANG Hong-Wu;LUO Hong-Yan;ZHENG Xiao-Lin;YANG Zhong;HU Ning;LIAO Yan-Jian;YANG Jun(Key Laboratory of Biorheologieal Science and Technology,Chongqing University,Ministry of Education,and Key Lab of Visual Damage and Regeneration ＆ Restoration of Chongqing,Bioengineering College,Chongqing University,Chongqing 400030,China;School of Economies and Business Administration,Chongqing University,Chongqing 400030,China;Department of Laboratory Medicine,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)

机构地区：[1]重庆大学生物工程学院生物流变科学与技术教育部重点实验室视觉损伤与再生修复重庆市重点实验室,重庆400030 [2]重庆大学经济与工商管理学院,重庆400030 [3]第三军医大学西南医院检验系,重庆400038

出　　处：《分析化学》2018年第8期1269-1274,共6页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.81501617);国家国际科技合作专项(No.2014DFG31380);中央高校基本科研业务费"研究生科技创新基金"项目(No.CDJXS11230046)资助~~

摘　　要：建立了一种新的基于微流控液滴形成技术的聚乙烯醇(Poly(vinyl alcohol),PVA)微球制备方法。在微流控芯片上利用液滴形成技术可以快速、连续产生尺度均一、单分散性好的PVA液滴。液滴制备速度可以达到7个/s。并且通过改变制备液中两相流体的注入流量和微流控通道宽度可对生成的PVA液滴的尺寸进行调节。将收集得到的PVA液滴进行物理交联固化处理,可以获得大量尺寸均一的聚乙烯醇微球。本方法制备效率高,所得到的微球单分散效果好,而且微球形成不需要化学交联剂的掺入,避免了对包载物质的干扰,非常适合药物载体等应用。A new method is used to prepare poly（ vinyl alcohol）（ PVA） microspheres. Droplet formation technology can produce a large number of uniform scale and monodisperse PVA droplets on the microfluidic chip quickly and continuously,and the droplet preparation speed can reach 6/sec. The size of the PVA droplets can be controlled by changing the injection flow rate of the two-phase fluid and the width of microfluidic channel. Then the PVA microspheres are formed by physical crosslinking. This method has high preparation efficiency and good monodisperse effect of the obtained microspheres. Moreover,the process does not require the incorporation of chemical crosslinking agents,avoiding interference with the inclusion material,and is well suited for applications such as drug carrier.

关 键 词：聚乙烯醇 微流控芯片 液滴 物理交联 聚乙烯醇微球 

分 类 号：O632.31[理学—高分子化学] TQ460.1[理学—化学]