植物三七中皂苷类化学成分的研究进展  

Researchprogress of Chemical constituents of saponins in Panax Notoginseng

作　　者：张静静 刘桂芹 王庆鹏 李兰杰 ZHANG Jing jing;LIU Gui qin;WANG Qing peng;LI Lan jie(Institute of BioPharmaceutical Research,Liaocheng University,Liaocheng 252059,Chin)

机构地区：[1]聊城大学生物制药研究院,山东聊城252059

出　　处：《聊城大学学报（自然科学版）》2018年第2期43-52,59,共11页Journal of Liaocheng University:Natural Science Edition

基　　金：国家自然科学基金资助课题(31701827);山东省抗体制药协同创新中心开放课题(CIC-AD1843);聊城大学博士基金(318051636)

摘　　要：三七总皂苷是中药三七[Notoginseng Radixet Rhizoma]的主要活性成分,具有止血与活血、改善心脑血管系统、抗炎、抗肿瘤和提高机体免疫力等药理作用,三七总皂苷的研究得到了广泛关注,成为中药研究中的重要领域,研究十分活跃.本文结合作者的工作基础及国内外相关文献,对三七中的皂苷类化学成分按照结构类型、皂苷来源进行了系统归纳,综述了三七活性成分在止血、活血、抗炎、抗肿瘤、提高免疫力等方面的药理作用,以期为三七中皂苷类成分的进一步研究提供参考.Saponins as the main effective constituent of Sanqi,are widely used in the treatment of stroke hemiplegia,cerebral infarction,cerebral thrombosis,cerebral hemorrhage sequelae,and retinal vein occlusion etc.The investigation on notoginseng has become an active and hot topic in traditional Chinese drugs.A great deal of effort has been devoted to this field,and many remarkable results were achieved.Herein,combining with authors＇ researches and referring to the works from literatures,the research progress of chemical constituents of saponins in Panax notoginsengare systematically reviewed in this article based on the structure and source.Their pharmaceutical activities in hemostasis,promoting blood circulation,anti-inflammatory,antitumor,immunity enhancement effects were also presented with the aim of providing new reference for further study of saponins in sanqi in the future.

关 键 词：三七 化学成分 皂苷类 三七皂苷 人参皂苷 

分 类 号：R932[医药卫生—生药学]