基于双路外周脉波的中心动脉压无创监测系统设计与实现  

Design and Implementation of Non-invasive Central Aortic Pressure Monitoring System Based on Two Peripheral Pulse Waves

作　　者：王璐 徐礼胜[2] 纪宁 齐林[2] 郝丽玲[2] WANG Lu;XU Lisheng;JI Ning;QI Lin;HAO Liling(School of Computer Science and Engineering;Sino-Dutch Biomedical and Information EngineeringSchool,Northeastern University,Shenyang Liaoning 110169,China)

机构地区：[1]东北大学计算机科学与工程学院,辽宁沈阳110169 [2]东北大学中荷生物医学与信息工程学院,辽宁沈阳110169

出　　处：《中国医疗设备》2018年第8期15-20,共6页China Medical Devices

基　　金：国家自然科学基金(61374015;61202258);中央高校基本科研业务费探索导向重点项目(N161904002;N130404016)资助项目(N172008008)

摘　　要：中心动脉压力波形对心血管疾病的预测与评价具有重要意义。针对目前无创法测量未充分考虑到个体差异与人体心血管系统时变特性的问题,本文将人体心血管系统假设为短时时不变系统,设计了一种基于双路外周动脉脉搏波的中心动脉压力脉搏波无创监测系统。通过两路袖带测量外周动脉血压与脉搏波,采用盲辨识Cross-Relation算法重建中心动脉压力波形。与临床应用广泛的澳大利亚At Cor公司Sphygmo Cor系统的检测结果相比,本系统中心动脉收缩压误差为(-1.8±5.6)mm Hg,舒张压误差为(-3.2±4.3)mm Hg,波形形态误差小,符合血压计性能评估的美国AAMI标准与英国BHS标准,实现了中心动脉压力波的个体化无创测量。The central aortic pressure has important signifcance in prediction and evaluation of cardiovascular diseases. However, individual differences and the time-varying characteristics of human cardiovascular system couldn’t be taken into full account in current noninvasive methods. This paper designed a noninvasive central aortic pressure monitoring system based on two peripheral arterial pulse waves by assuming the human cardiovascular system as a kind of short-time invariant system. In the proposed system, the central aortic pulse was dynamically reconstructed based on the Cross-Relation dual-channel blind identification algorithm using two peripheral arterial blood pressures and pulse waves which were measured simultaneously by two cuffs. In comparison with the clinical widely-used SphygmoCor system （AtCor, Australian）, the error of aortic systolic and diastolic blood pressure was （-1.8±5.6） mmHg and （-3.2±4.3） mmHg respectively, which was in consistent with the US AAMI standard and the British BHS standard requirement. The noninvasive central aortic pressure monitoring system can individually measure the central aortic pulse wave in an noninvasive way.

关 键 词：无创测量 个性化 中心动脉压 盲辨识 CR算法 

分 类 号：N945.14[自然科学总论—系统科学]