慢性乙型肝炎病毒感染与冠心病的相关性  

Correlation between chronic hepatitis B virus infection and coronary heart disease

作　　者：赵健[1] 望云[2] 魏博[3] 贺治青[1] 梁春[1] ZHAO Jian;WANG Yun;WEI Bo;HE Zhi-qing;LIANG Chun(Department of Cardiovasology,Changzheng Hospital,Navy Medical University（Second Military Medical University）,Shanghai 200003,China;Department of Medical Image,Changzheng Hospital,Navy Medical University（Second Military Medical University）,Shanghai 200003,China;Department of Infectious Diseases,Changzheng Hospital,Navy Medical University（Second Military Medical University）,Shanghai 200003,China)

机构地区：[1]海军军医大学(第二军医大学)长征医院心血管内科,上海200003 [2]海军军医大学(第二军医大学)长征医院影像诊断科,上海200003 [3]海军军医大学(第二军医大学)长征医院感染科,上海200003

出　　处：《第二军医大学学报》2018年第7期794-797,共4页Academic Journal of Second Military Medical University

基　　金：上海市医学领军人才项目(LJRC2015-21)~~

摘　　要：目的探讨慢性乙型肝炎病毒(H B V)感染与冠心病的相关性,为冠心病的预防提供决策依据。方法纳入2013年1月至2017年6月在我院行冠状动脉计算机断层扫描血管造影(CTA)检查,且既往无冠心病史的健康体检者759例,按照乙型肝炎病毒表面抗原检查结果将其分为HBV感染组(38例,均为慢性HBV感染)和对照组(721例),比较两组冠状动脉病变情况,并分析慢性HBV感染与冠心病的相关性。结果经冠状动脉CTA检查,两组冠心病的患病率差异无统计学意义[21.05%(8/38)vs 28.02%(202/721),P>0.05]。HBV感染组的冠状动脉病变血管支数、斑块类型及斑块病变血管支分布与对照组比较差异均无统计学意义(P均>0.05)。双变量相关分析结果显示慢性HBV感染与冠心病无相关关系(r=0.034,P>0.05)。结论慢性HBV感染与冠心病之间无临床相关性。Objective To investigate the correlation between chronic hepatitis B virus（HBV） infection and coronary heart disease（CHD）, so as to provide basis for decision-making in the prevention of CHD. Methods A total of 759 healthy volunteers without history of CHD, who received coronary computed tomography angiography（CTA） examination between Jan. 2013 and Jun. 2017 in our hospital, were included in the study. According to the levels of hepatitis B virus surface antigen（HBs Ag）, they were divided into HBV infection group（38 cases, all had chronic HBV infection） and control group（721 cases）. Then we compared coronary artery lesions between the two groups, and analyzed the correlation between chronic HBV infection and CHD. Results Coronary CTA examination results showed that there was no significant difference in the prevalence of CHD between the two groups（21.05%[8/38] vs 28.02%[202/721], P〉0.05）. In addition, there were no significant differences in the number of coronary artery lesions, the type of plaque lesions or the distribution of diseased vessels with plaque between the HBV infection group and the control group（all P〉0.05）. Bivariate correlation analysis showed that there was no correlation between chronic HBV infection and CHD（r=0.034, P〉0.05）. Conclusion There is no clinical correlation between chronic HBV infection and CHD.

关 键 词：乙型肝炎病毒 冠心病 冠状动脉计算机断层扫描血管造影 相关性 

分 类 号：R541.4[医药卫生—心血管疾病] R373.21[医药卫生—内科学]