柯萨奇A6型病毒致重症手足口病危险因素分析  

Analysis on risk factors of severe cases with hand foot mouth disease infected by Coxsackievirus A6

作　　者：熊田甜[1] 孟瑜 刘坚[3] 黄娇 赵荣仙 吴泰顺[1] 魏晟[2] XIONG Tian-tian;MENG Yu;LIU Jian;HUANG Jiao;ZHAO Rong-xian;WU Tai-shun;WEI Sheng(Bao an District Center for Disease Control and Prevention,Guangdong Shenzhen 508101,China)

机构地区：[1]深圳市宝安区疾病预防控制中心,广东深圳508101 [2]华中科技大学公共卫生学院 [3]深圳市宝安区人民医院

出　　处：《江苏预防医学》2018年第4期374-377,共4页Jiangsu Journal of Preventive Medicine

基　　金：深圳市科技计划项目(JCYJ20150403094740975);深圳市宝安区科技计划项目(2015305)

摘　　要：目的探讨柯萨奇A6型病毒(CVA6)感染所致重症手足口病的危险因素。方法采用1∶1匹配的病例对照研究方法,收集深圳市宝安人民医院2015年5月-2016年11月实验室确诊的CVA6感染所致重症和轻症手足口病例各101例,采用向后逐步回归的多因素logistic回归方法筛选影响因素。结果出现丘疹、患儿经常咬玩具、照看人文化程度高中以下和发热最高体温≥39℃为CVA6感染所致重症的危险因素,母乳喂养和发病诊断时间间隔较短为保护因素。结论及早诊断和母乳喂养可降低CVA6所致重症手足口病风险,丘疹和高热可作为手足口病重症早期识别指征。Objective To explore the risk factors of severe cases of hand-foot-mouth disease（HFMD）infected by Coxsachievirus A6（CVA6）.Methods A 1∶1 case control study were conducted,in which 101 severe HFMD cases and 101 mild cases infected by CVA6 confirmed by laboratory diagnosis were selected from Shenzhen Bao＇an People＇s Hospital from May 2015 to Nov 2016.Multiple regression logistic regression was used to screen the influencing factors.Results Logistic regression analysis showed that pimple,frequent biting toys,caregivers with education level of high school or lower and fever with body temperature of 39 ℃ or more were risk factors of severe HFMD infected by CVA6;breast feeding and short duration between onset and diagnosis were protective factors.Conclusion Early diagnosis and breast feeding can reduce the risk of severe HFMD infected by CVA6,pimple and high fever could be the early indicators of severe HFMD.

关 键 词：手足口病 重症 柯萨奇病毒A6型 危险因素 

分 类 号：R512.5[医药卫生—内科学]