影响神经递质的补益中药药理学研究进展  

Research progress of pharmacology of tonic Chinese medicinal for influencing neurotransmitters

作　　者：张翕婷 王怡[1] 李霖 陈婷 邸晶蕊 晏一淇 张晗[1,2] ZHANG Xiting, WANG Yi, LI Lin, et al.(Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chin)

机构地区：[1]天津中医药大学中医药研究院,300193 [2]天津市现代中药重点实验室

出　　处：《环球中医药》2018年第7期1164-1169,共6页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(81630106);国家重点基础研究发展计划(973计划)(2012CB518404)

摘　　要：现代药理研究表明,补虚药可以调节免疫,抗疲劳、抗应激、抗衰老、提高脑力活动、调节神经系统。其中神经递质的改变会影响人体某些生理及病理变化,例如可以影响学习记忆,产生疲劳,参与抑郁和神经退行性疾病的发生发展。目前发现,补虚药可能通过调节五羟色胺、多巴胺、去甲肾上腺素等神经递质改善机体学习记忆,减轻运动疲劳反应,发挥抗抑郁作用,延缓神经退行性疾病发展。本文就补虚药影响神经递质调节机体生理和病理变化做一综述。Modern pharmacological studies have shown that the tonifying deficiency Chinese medicinal can regulate immunity,anti-fatigue,anti-stress,anti-aging,increase mental activity,and regulate the nervous system. The change of neurotransmitter can affect certain physiological and pathological changes of human body. For example,it can affect learning and memory,generate fatigue,and participate in the development of depression and neurodegenerative diseases. At present,it was found that the tonifying deficiency Chinese medicinal may improve the body learning and memory by regulating the neurotransmitter,reduce the motor fatigue response,play an anti-depressant role and delay the development of neurodegenerative diseases by regulating neurotransmitters such as serotonin（ 5-HT）,dopamine（ DA）,norepinephrine（ NE）. This paper reviewed the effects of tonifying deficiency Chinese medicinal on physiological and pathological changes of neurotransmitters.

关 键 词：补益中药 神经递质 改善记忆 抗疲劳 抗抑郁 延缓神经退行性病变 

分 类 号：R285[医药卫生—中药学]