喜炎平辅助治疗小儿急性化脓性扁桃腺炎的疗效观察  

Effect of adjuvant therapy with Xi Yan Ping on the acute suppurative tonsillutis in children

作　　者：宋颖燕[1] 王俊霞[1] 冯冬娥 华琳[2] 张玉和[1] SONG Ying-yan;WANG Jun-xia;FENG Dong-e;HUA Lin;ZHANG Yu-he(Beijing Renhe hospital,Beijing 102600,China;Biostatistics and bioinformatics of capital medical university,Beijing 100069,China)

机构地区：[1]北京市仁和医院儿科,北京102600 [2]首都医科大学,北京100069

出　　处：《临床医药文献电子杂志》2018年第29期8-9,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的讨论喜炎平注射液辅助治疗小儿急性化脓性扁桃腺炎的临床效果及不良反应。方法选择2015年6月~2016年6月在我院儿科门诊因急性化脓性扁桃腺炎就诊的5岁至14岁的患儿,共143例为研究对象,随机分为两组,实验组68例(疗效统计数据为67例,1例因不良事件停止用药,未获取疗效数据),对照组75例,两组患儿均根据年龄和体重给予头孢呋辛不等量静点。在此基础上,对照组给予生理盐水静点,实验组在生理盐水中加入喜炎平注射液0.2~0.4 ml/kg不等量静点。观察两组的临床疗效和不良反应。结果实验组退热天数的中位数和四分位数间距为2(2,3)天,对照组为4(3,4)天;实验组脓胎消退时间的中位数和四分位数间距为3(3,4)天,对照组为4(4,5)天;两组均有统计学意义(P<0.05)。两组治疗3天后复查末梢血,实验组中白细胞计数下降(5.72±1.46)×10~9,CRP下降11.70±4.27;对照组白细胞计数下降(3.67±1.13)×10~9,CRP下降4.73±2.38,两组比较均有统计学意义(P<0.05)。治疗组患儿中有一例输注喜炎平后出现少量皮疹,停药后1天消退。不良反应发生率1.47%。结论喜炎平治疗小儿急性化脓性扁桃腺炎的疗效好,不良反应发生率低,可以考虑在临床广泛推广。Objective To evaluate the clinical effects and adverse reactions of Xiyanping injection on the auxiliary treatment of pediatric acute suppurative tonillitis.Methods Weselected 143 young children aged from 5 to 14 years old who had acute suppurative tonillitis from June 2015 to June 2016 as the research object.Randomly divided into two groups.The 68 cases were the experimental group and the 75 cases were the control group.Due to one case of a skin rash,dropped out.It is no statistical difference in age and sex between the two groups.The two groups of children were given cefuroxime sodium for injection.In addition to this,the control group given normal saline infusion,the experience group add Xiyanping in normal saline infusion.Observe two groups of clinical effect and adverse reactions.Results The median and interquartile range of pyretolysis days in experience group is 2（2,3）days,the control grou is 4（3,4）days;The median and interquartile range of extinction time of pus in experience group is 3（3,4）days,the control grou is 4（4,5）days.The two groups were statistically significant（P〈0.05）.The two groups were treated with peripheral blood after 3 days,The WBC in the experimental group decreased by（5.72±1.46）×10~9;The CRP decreased by 4.73±2.38.The two groups were statistically significant（P〈0.05）.One of the children in the treatment group appeared a small dose of rash after infusion of Xi Yan Ping,one day after withdrawal.The incidence of adverse reactions was 1.47%.Conclution The therapy of Xi Yan Ping for children with suppurative tonsillitis,low incidence of adverces,is effective and can consider to be widely applied in clinical practice.

关 键 词：急性化脓性扁桃腺炎 喜炎平 小儿 疗效 

分 类 号：R725.6[医药卫生—儿科]