老年高血压患者颈动脉硬化与血清C反应蛋白、脂蛋白(a)及尿酸的相关性分析  

Correlation between Carotid Atherosclerosis and Serum C-reactive protein,Lipoprotein(a) and Uric Acid in Elderly Hypertensive Patients

作　　者：沈秀张[1] SHEN Xiu-zhang(Department of Health Care,Zhongshan Hospital,Xiamen University,Xiamen,Fujian Province,361004 China)

机构地区：[1]厦门大学附属中山医院保健病房,福建厦门361004

出　　处：《中外医疗》2018年第15期16-18,共3页China & Foreign Medical Treatment

摘　　要：目的探讨老年高血压患者颈动脉硬化与血清C反应蛋白(CRP)、脂蛋白(a)及尿酸(BUA)的相关性。方法方便选取2015年5月—2016年10月该院内科病房收治的46例高血压合并颈动脉硬化患者,根据颈动脉内膜中层厚度(IMT)检测结果分为IMT增厚组(1.0 mm<IMT≤1.2 mm,n=21)和颈动脉斑块形成组(IMT≥1.2 mm,n=25),选取同期健康体检老年人(IMT≤1.0 mm)15名纳入对照组,检测3组受试者血清CRP、脂蛋白(a)及BUA值。结果 IMT增厚组与颈动脉斑块形成组的血清CRP[(9.20±2.41)mg/L vs(11.07±4.56)mg/L]、脂蛋白(a)[(325.18±76.59)mg/L vs(389.55±80.22)mg/L]及BUA[(499.65±49.50)mmol/L vs(541.20±52.36)mmol/L]表达水平均显著高于对照组(P<0.05),随着IMT值的增加,相关生化指标表达水平也相应升高,多因素Logistic回归分析显示血清CRP(P=0.003)、脂蛋白(a)(P=0.027)及BUA(P=0.000)均是颈动脉硬化的独立危险因素。结论血清C反应蛋白、脂蛋白(a)及尿酸与老年高血压患者颈动脉硬化程度关系密切,可作为判断颈动脉内膜中层厚度的参考指标。Objective This paper tries to investigate the correlation between carotid atherosclerosis and serum C reactive protein（CRP）, lipoprotein（a） and uric acid（BUA） in elderly patients with hypertension. Methods From May 2015 to October 2016, 46 hypertensive patients with carotid atherosclerosis admitted to our department were convenient selected and divided into IMT thickening group according to the carotid intima-media thickness（IMT） test results（1.0 mmIMT≤ 1.2 mm,n=21） and carotid plaque formation group（IMT ≥ 1.2 mm, n=25）, and 15 healthy subjects（IMT ≤ 1.0 mm） in the same period were included in the control group to test the serum CRP, lipoprotein（a） and BUA values of the three groups of subjects. Results Serum CRP [（9.20 ±2.41）mg/L vs（11.07 ±4.56） mg/L] and lipoprotein（a） [（325.18 ±76.59）mg/L vs（389.55 ±80.22） mg/L] in the IMT thickening group and the carotid plaque formation group The expression levels of L] and BUA[（499.65±49.50）mmol/L vs（541.20±52.36） mmol/L] were significantly higher than those in the control group（P0.05）. With the increase of IMT value, the expression level of related biochemical indicators also increased accordingly. Multivariate logistic regression analysis showed that serum CRP（P =0.003）, lipoprotein（a）（P =0.027）, and BUA（P =0.000） were independent risk factors for carotid atherosclerosis. Conclusion Serum C-reactive protein, lipoprotein（a） and uric acid are closely related to carotid atherosclerosis in elderly hypertensive patients and can be used as a reference index for judging carotid intima-media thickness.

关 键 词：老年高血压 颈动脉硬化 血清C反应蛋白 脂蛋白A 血清尿酸 

分 类 号：R544.1[医药卫生—心血管疾病]