哌拉西林钠他唑巴坦钠用于新生儿感染治疗的可行性  

Feasibility of Using Piperacillin Sodium and Tazobactam Sodium in Neonatal Infection Treatment

作　　者：孔莉 KONG Li(Department of Pediatrics,First People＇s Hospital of Honghe Prefecture,Mengzi,Yunnan Province,661199 China)

机构地区：[1]云南省红河州第一人民医院儿科,云南蒙自661199

出　　处：《中外医疗》2018年第15期130-132,共3页China & Foreign Medical Treatment

摘　　要：目的探讨青霉素G钠联合哌拉西林钠他唑巴坦钠治疗新生儿感染的应用效果。方法方便选取2016年6月—2017年7月90例新生儿感染患儿,以数字表法分组。对照组给予单一青霉素G钠治疗,观察组则给予青霉素G钠联合哌拉西林钠他唑巴坦钠治疗。比较两组新生儿感染控制率;感染控制时间、细菌培养转阴时间;干预前后患儿免疫指标、炎症指标;皮疹等不良反应发生率。结果观察组新生儿感染控制率43例(95.56)%高于对照组31例(68.89)%,差异有统计学意义(χ~2=10.946,P<0.05);观察组感染控制时间、细菌培养转阴时间(6.11±1.41)、(7.13±0.46)d短于对照组(7.42±2.25)、(8.23±1.51)d,差异有统计学意义(t=8.214、9.174,P<0.05);干预后观察组C反应蛋白、免疫球蛋白-G、TNF-α、白介素-(63.01±0.24)mg/L、(8.13±0.51)g/L、(21.45±2.18)ng/L、(5.13±0.16)pg/m L优于对照组(6.13±0.25)mg/L、(6.92±0.55)g/L、(27.13±2.14)ng/L、(8.21±0.22)pg/m L,差异有统计学意义(t=6.982、9.824、8.733,7.923,P<0.05)。观察组皮疹等不良反应发生率和对照组差异无统计学意义(χ~2=0.244,P>0.05)。其中,对照组有4例出现皮疹,观察组有3例出现皮疹。结论青霉素G钠联合哌拉西林钠他唑巴坦钠治疗新生儿感染的应用效果确切,可有效控制感染,改善症状,缩短疗程,改善炎症和免疫指标,且无严重不良反应,安全有效,值得推广应用。Objective This paper tries to investigate the effect of penicillin G combined with piperacillin and tazobactam sodium in the treatment of neonatal infection. Methods 90 children with neonatal infection from June 2016 to July 2017 were convenient selected and grouped by digital representation. The control group was given a single penicillin G sodium treatment, and the observation group was given penicillin G sodium combined with piperacillin sodium tazobactam sodium treatment. The infection control rate of the two groups was compared; the time of infection control and the time of bacterial culture negative; the immune index and inflammation index of the children before and after the intervention; the incidence of adverse reactions such as rash. Results The rate of neonatal infection control in the observation group was 43 case（95.56）% higher than that of the control group 31 case（68.89）%, the difference nce was statistically significant（χ2=10.946,P〈0.05）; the infection control time of the observation group, bacterial culture negative time was（6.11±1.41）d,（7.13±0.46）d was shorter than the control group of（7.42±2.25）d,（8.23±1.51）d,the difference nce was statistically significant（t=8.214,9.174, P〈0.05）; after intervention, the observation group was C-reactive protein, immunoglobulin-G, TNF-α, interleukin-（63.01±0.24）mg/L,（8.13 ±0.51）g/L,（21.45 ±2.18）ng/L, and（5.13 ±0.16）pg/m L were better than the control group（6.13 ±0.25）mg/L,（6.92 ±0.55）g/L,（27.13 ±2.14）ng/L, and（8.21 ±0.22）pg/m L, the difference nce was statistically significant（t =6.982, 9.824, 8.733, 7.923, P〈0.05）. There was no significant difference in the incidence of adverse reactions such as skin rash between the observation group and the control group（χ2=0.244, P〈0.05）. Among them, there were 4 cases of rash in the control group and 3 cases of rash in the observation group. Conclusion Penicillin G sodium combined with piperacillin sodium and tazobactam sodium in

关 键 词：青霉素G钠 哌拉西林钠他唑巴坦钠 新生儿感染 应用效果 

分 类 号：R722.13[医药卫生—儿科]