稳斑汤联合体外反搏治疗冠心病经皮冠状动脉介入治疗术后患者的临床疗效及对血清血栓素A2、前列腺素I2、TNF-α、单核细胞趋化蛋白-1的影响  

Clinical Efficacy of Wenban Decoction Combined with Enhanced External Counterpulsation in the Treatment of PCI Postoperative Patients with Coronary Heart Disease and the Influence on Serum TXA_2,PGI_2,TNF-α and MCP-1

作　　者：姜丹[1] 宫丽鸿[2] Jiang Dan;Gong Lihong(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Hospital Affiliated to Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学,沈阳110032 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《世界中医药》2018年第6期1439-1443,共5页World Chinese Medicine

基　　金：国家重点基础研究发展计划("973计划")项目(2014CB542903);国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015033);沈阳市心血管康复技术重点实验室建设项目(F14-189-1-00);辽宁省重点专科能力建设项目中医药临床专科能力建设项目

摘　　要：目的:观察稳斑汤联合增强型体外反搏治疗冠心病经皮冠状动脉介入治疗(PCI)术后患者的临床疗效及对血清血栓素A2(TXA_2)、前列环素2(PGI_2),TNF-α/单核细胞趋化蛋白-1(MCP-1)的影响,探讨其疗效机制。方法:选取2014年10月至2016年2月辽宁中医药大学附属医院就诊的符合纳入标准的冠心病PCI术后(痰瘀互结证)患者60例,随机分为观察组和对照组,每组30例。对照组采用常规西药加稳斑汤治疗,观察组在对照组基础上联合体外反搏治疗,疗程均为35 d,疗程前后对2组临床疗效,血清TXA_2、PGI_2、TNF-α、MCP-1水平进行比较分析。结果:与治疗前比较,治疗后2组临床疗效、血清TXA_2、PGI_2、TNF-α、MCP-1比较,差异有统计学意义(P<0.05);观察组优于对照组,差异有统计学意义(P<0.05)。结论:稳斑汤联合体外反搏治疗能有效改善冠心病PCI术后患者的临床疗效,改善血管内皮功能和降低炎性反应递质水平可能是其作用机制之一。Objective： To observe the clinical efficacy of Wenban Decoction combined with enhanced external counterpulsation in the treatment of PCI postoperative patients with coronary heart disease and the influence on serum TXA_2,PGI_2,TNF-α and MCP-1.Methods： A total of 60 PCI postoperative patients with coronary heart disease（ turbid phlegm and blood stasis） were randomly divided into treatment group and control group with 30 patients in each group.The control group was treated by conventional western medicine and Wenban decoction,and the treatment group was added enhanced external counterpulsation on the basis of the control group with a course of 35 days.The clinical efficacy and the content of serum TXA_2,PGI_2,TNF-α,MCP-2 before and after the treatment were compared.Results： After the course of treatment,compared with before treatment,the treatment group and the control group had statistically significant differences（ P〈0.01; P〈0.05） in the clinical efficacy and the content of serum TXA_2,PGI_2,TNF-α,MCP-1; Comparing between groups,the treatment group had statistically significant differences（ P〈0.01;P〈0.05） in the clinical efficacy and the content of serum TXA_2,PGI_2,TNF-α,MCP-1 from the control group.Conclusion：Wenban decoction combined with enhanced external counterpulsation could effectively improve the clinical efficacy of PCI postoperative patients with coronary heart disease,and improving vascular endothelial function and reducing the level of inflammatory factors may be one of its mechanisms.

关 键 词：稳斑汤 体外反搏 冠心病 经皮冠状动脉介入治疗 血栓素A2 前列环素2 TNF-α/单核细胞趋化蛋白-1 中药 内皮功能 炎性因子 

分 类 号：R289.5[医药卫生—方剂学] R541.4[医药卫生—中药学]