益气养阴法联合TACE治疗中晚期肝癌患者的疗效观察  

Efficacy Observation on Replenishing Qi and Nourishing Yin Method Combined with Transcatheter Arterial Chemoembolization in the Treatment of Middle and Late Stage Liver Cancer

作　　者：张超 连淑峰 赵婷 孙剑经[3] 张林西[4] Zhang Chao;Lian Shufeng;Zhao Ting;Sun Jianjing;Zhang Linxi(Department of Intervention,First Hospital Affiliated to Hebei Northern University,Zhangjiakou 07500,China;Department of Maternal and Child Heahheare,Zhangjiakou 07500,China;Department of Digestive,First Hospital Affiliated to Hebei Northern University,Zhangjiakou 07500,China;Basic Medical College of Hebei North University,Zhangjiakou 075000)

机构地区：[1]河北北方学院附属第一医院介入科,张家口075000 [2]张家口市桥西区妇幼保健站妇幼保健科,张家口075000 [3]河北北方学院附属第一医院消化科,张家口07500 [4]河北北方学院基础医学院,张家口075000

出　　处：《世界中医药》2018年第6期1461-1463,1468,共4页World Chinese Medicine

基　　金：河北省高等学校科学技术研究重点项目(ZD20131004)

摘　　要：目的:探讨益气养阴法联合肝动脉化疗栓塞术(TACE)治疗中晚期肝癌患者的临床疗效。方法:选取2013年3月至2016年3月在河北北方学院附属第一医院介入科收治的中晚期肝癌患者92例。按照随机表法,将患者随机分为观察组和对照组,每组46例。对照组给予TACE治疗,观察组在对照组的基础上联合益气养阴法。治疗两周后,观察2组患者临床疗效、生命质量、肝功能指标和血常规以及不良反应的发生率。结果:观察组有效率(89.13%)明显大于对照组有效率(76.09%)(P<0.05);观察组治疗前与对照组治疗前患者TBil、AST、ALT、RBC、WBC、PLT比较,差异无统计学意义(P>0.05);2组治疗前与治疗后患者TBil、AST、ALT、RBC、WBC、PLT比较均有改善作用(P<0.05);观察组在改善患者TBil、AST、ALT、RBC、WBC、PLT方面均优对照组(P<0.05);观察组生命质量的改善情况明显优于对照组(P<0.05);观察组不良反应的发生率明显优于对照组(P<0.05)。结论:益气养阴法联合TACE治疗中晚期肝癌患者能明显改善患者临床疗效、肝功能以及生命质量,而在不良反应发生率方面优于单纯TACE,值得临床推广。Objective： To investigate the clinical effect of the treatment of middle and late stage hepatocellular carcinoma by the method of replenishing qi and nourishing yin combined with hepatic artery chemoembolization（ TACE）.Methods： A total of 92 cases of middle and advanced stage hepatocellular carcinoma treated in the Department of Intervention of the First Hospital Affiliated with Hebei Northern University from March 2013 to March 2016 were selected.The patients were randomly divided into observation group（ n = 46） and control group（ n = 46） according to random table method.The control group was treated with TACE,and the observation group was treated combined with the method of replenishing qi and nourishing yin.After two weeks of treatment,the clinical curative effect,quality of life,liver function index,blood routine and the incidence of adverse reactions were observed.Results： The efficiency of observation group（ 89.13 %） was significantly higher than that of control group（ 76.09 %）（ P〈0.05）.There was no significant difference between the observation group and the control group in TBil,AST,ALT,RBC,WBC and PLT（ P〈0.05）.TBil,AST,ALT,RBC,WBC and PLT of the two groups were improved after treatment（ P〈0.05）.The observation group was superior to the control group（ P〈0.05） in the improvement of Ttil,AST,ALT,RBC,WBC and PLT.The improvement of quality of life in the observation group was significantly better than that in the control group（ P〈0.05）.The incidence of adverse reactions in the observed group was significantly better than that in the control group（ P〈0.05）.Conclusion： Replenishing qi and nourishing yin method combined with TACE in treating patients with middle-and advanced stage hepatocellular carcinoma can significantly improve the clinical efficacy,liver function and quality of life,and the incidence of adverse reactions is better than that of simple TACE,which is worthy of clinical promotion.

关 键 词：益气养阴法 肝动脉化疗栓塞术 中晚期肝癌 临床疗效 

分 类 号：R242[医药卫生—中医临床基础] R735.7[医药卫生—中医学]